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In addition, margination of well\u2010developed beta granules, and emiocytotic events were observed as early as the fifth embryonic day. The initial appearance of insulin, together with its subsequent developmental profile, correlate well with major metabolic events occurring in the embryonic chick, and are discussed in relation to a functionally responding system, the developing liver. The present data show that the chick endocrine pancreas has the potential for activity very early in development, and that insulin may be secreted at earlier embryonic stages than hitherto accepted.<\/jats:p>","DOI":"10.1002\/ar.1091800308","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T22:25:42Z","timestamp":1109456742000},"page":"491-496","source":"Crossref","is-referenced-by-count":27,"title":["Functional differentiation of the chick endocrine pancreas: Insulin storage and secretion"],"prefix":"10.1002","volume":"180","author":[{"given":"Camillo A.","family":"Benzo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim D.","family":"Green","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,1,27]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"Carbohydrate Metabolism and its Disorders","author":"Ashmore J.","year":"1968"},{"key":"e_1_2_1_3_1","first-page":"277","article-title":"Insulin requirement for development of chick embryo liver during organ culture","volume":"169","author":"Benzo C. 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