{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T04:40:22Z","timestamp":1699764022486},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,1,27]],"date-time":"2005-01-27T00:00:00Z","timestamp":1106784000000},"content-version":"vor","delay-in-days":10772,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat. Rec."],"published-print":{"date-parts":[[1975,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Both the NZW and NZB mice exhibit an elevated fasting blood sugar level when compared to Swiss white mice. The NZB\/NZW F<jats:sub>1<\/jats:sub> hybrid mouse shows still a higher fasting serum glucose level than either of its parental strains. This elevated glucose level is noted very early in the animals' life, long before definitive signs or symptoms of pathology are evident, and remains elevated at least until the fortieth week of life, the last testing period in our series before sacrificing the animals. There are two major peaking periods for the glucose levels, namely at 4\u201310 weeks of age and then again at 31\u201340 weeks of age. These age periods correspond to the very young animal and to the animal that is beyond its prime and most likely sick and near the end of its lifespan due to the animals' inherent disease processes. The NZB and NZB\/NZW F<jats:sub>1<\/jats:sub> hybrid succumb to their disease processes at approximately 8\u201310 months of age. The NZW usually lives until 18 months.<\/jats:p><jats:p>The questions are raised: does the altered immunologic state in the NZB and\/or the NZB\/NZW F<jats:sub>1<\/jats:sub> hybrid produce the elevated blood sugar levels and the pancreatic histopatholgy or is it the early hyperglycemic condition coupled with pancreatic pathology which are in some measure instrumental in producing the lesions discussed and observed, in the beginning of the three to four month period of age, in the various organs? Is there a relationship between the hyperglycemic condition and the immune state or are these independent phenomena in a genetically \u201cmixed up\u201d mouse?<\/jats:p>","DOI":"10.1002\/ar.1091820403","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T07:39:33Z","timestamp":1109403573000},"page":"415-430","source":"Crossref","is-referenced-by-count":1,"title":["Hyperglycemia in the NZB\/NZW F<sub>1<\/sub> hybrid mouse"],"prefix":"10.1002","volume":"182","author":[{"given":"B.","family":"Pansky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. S.","family":"Kessler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Senitzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,1,27]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.12.4.327"},{"key":"e_1_2_1_3_1","first-page":"84","volume-title":"Blood and other body fluids","author":"Dittmer D. 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Med."}],"container-title":["The Anatomical Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Far.1091820403","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.1091820403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T04:18:46Z","timestamp":1699762726000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ar.1091820403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,8]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1975,8]]}},"alternative-id":["10.1002\/ar.1091820403"],"URL":"https:\/\/doi.org\/10.1002\/ar.1091820403","archive":["Portico"],"relation":{},"ISSN":["0003-276X","1097-0185"],"issn-type":[{"value":"0003-276X","type":"print"},{"value":"1097-0185","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,8]]}}}