{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T18:13:28Z","timestamp":1760897608523},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,1,27]],"date-time":"2005-01-27T00:00:00Z","timestamp":1106784000000},"content-version":"vor","delay-in-days":10680,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat. Rec."],"published-print":{"date-parts":[[1975,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of magnesium deficiency in ovariectomized and estrogen\u2010treated rats were examined in histological sections of bones and various soft tissues. The changes observed in the femora of <jats:italic>intact<\/jats:italic> rats deprived of magnesium for three weeks were: 1. a general increase in diaphyseal thickness, 2. the presence of localized fibrous or bony\u2010like masses in subperiosteal and metaphyseal sites, and 3. the occurrence, although rare, of endosteal hyperplasia. In <jats:italic>ovariectomized<\/jats:italic>, magnesium\u2010deprived animals, the incidence and location of fibrous masses were similar to that in the femora of magnesium\u2010deficient <jats:italic>intact<\/jats:italic> rats; however, no increase in diaphyseal thickness was noted. Daily injections of 25 \u03bcg <jats:italic>estradiol<\/jats:italic> caused a reduction of the frequency of skeletal hyperplasia from 80% to 20%, as well as a reduction in femoral diaphyseal thickness. Estradiol hormone administration also brought about a marked alleviation of the dermal and neural manifestations of magnesium deficiency, but, at the same time, caused an exacerbation of renal calcinosis.<\/jats:p>","DOI":"10.1002\/ar.1091830308","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T07:39:18Z","timestamp":1109403558000},"page":"437-447","source":"Crossref","is-referenced-by-count":17,"title":["Skeletal effects of magnesium deficiency in normal, ovariectomized, and estrogen\u2010treated rats"],"prefix":"10.1002","volume":"183","author":[{"given":"Rita","family":"Bogoroch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard F.","family":"Belanger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,1,27]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091530106"},{"key":"e_1_2_1_3_1","first-page":"41","volume-title":"Histochemistry and Cytochemistry","author":"B\u00e9langer L. 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