{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:03:56Z","timestamp":1790881436094,"version":"4.1.0"},"reference-count":78,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,1,27]],"date-time":"2005-01-27T00:00:00Z","timestamp":1106784000000},"content-version":"vor","delay-in-days":10650,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat. Rec."],"published-print":{"date-parts":[[1975,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Renewal of the cell populations of the incisor was studied in 100 gm male rats injected with a single dose of <jats:sup>3<\/jats:sup>H\u2010thymidine and sacrificed at various times from one hour to 32 days after injection. Radioautographs showed that a cohort of labeled cells within the enamel organ, odontoblast layer, and pulp was carried passively with the erupting incisor from the apical end toward the gingival margin where the life cycle of these cells was terminated. Labeled cells in the upper and lower incisor, although traversing different absolute lengths, were found in approximately the same functional stage of their life cycle at similar times after the injection. Thus, by one and one\u2010half days labeled ameloblasts began inner enamel secretion. By 32 days labeled ameloblasts had traversed the entire maturation zone and were located at the gingival margin. Labeled odontoblasts followed closely the movement of labeled ameloblast. The mean rate of ameloblast migration was 567 \u03bcm\/day on the upper incisor and 651 \u03bcm\/day on the lower. For the odontoblasts this rate was 500 \u03bcm\/day (upper) and 631 \u03bcm\/day (lower). Finally, it was found that as the rat aged, the duration of the life cycle for epithelial and pulp cell populations of the incisor increased because of growth within the longitudinal axis of the tooth. It was concluded that the apical end of the incisor literally \u201cgrows backward\u201d in the bony socket, and hence, the duration of the life cycle becomes greater simply because it takes cells longer to physically reach the gingival margin.<\/jats:p>","DOI":"10.1002\/ar.1091830405","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T07:41:18Z","timestamp":1109403678000},"page":"523-561","source":"Crossref","is-referenced-by-count":156,"title":["Cellular renewal in the enamel organ and the odontoblast layer of the rat incisor as followed by radioautography using <sup>3<\/sup>H\u2010thymidine"],"prefix":"10.1002","volume":"183","author":[{"given":"C. E.","family":"Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Warshawsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,1,27]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1050260103"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345540330011601"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(72)90161-6"},{"key":"e_1_2_1_5_1","first-page":"970","article-title":"Distribution of 3H\u2010thymidine labeled cells in the incisor tooth of the rat","volume":"43","author":"Blackwood H. J. J.","year":"1964","journal-title":"J. dent. Res."},{"key":"e_1_2_1_6_1","first-page":"432","article-title":"An experimental evaluation of the physiology of tooth eruption","volume":"7","author":"Bryer L. W.","year":"1957","journal-title":"Int. dent. J."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345530320010601"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(67)90079-1"},{"key":"e_1_2_1_9_1","first-page":"425","volume-title":"Proceedings Dental Centenary Celebration","author":"Chase S. W.","year":"1940"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(65)90015-4"},{"key":"e_1_2_1_11_1","first-page":"986","article-title":"Movement, during unimpeded eruption, of the position of cells and of material incorporating tritiated proline, in the lingual periodontal membrane of the mandibular incisors of adult male mice","volume":"47","author":"Chiba M.","year":"1968","journal-title":"J. dent. Res."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(67)90109-4"},{"key":"e_1_2_1_13_1","first-page":"986","article-title":"Impeded and unimpeded eruption of the mandibular incisor of the adult male rat and its stoppage by demecolcine","volume":"47","author":"Chiba M.","year":"1968","journal-title":"J. dent. Res."},{"key":"e_1_2_1_14_1","first-page":"184","volume-title":"Thymidine Metabolism and Cell Kinetics","author":"Cleaver J. E.","year":"1967"},{"key":"e_1_2_1_15_1","first-page":"810","article-title":"Demonstration of odontoblast precursors cell by tritiated thymidine","volume":"43","author":"Cotton W. R.","year":"1964","journal-title":"J. dent. Res."},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345420210050201"},{"key":"e_1_2_1_17_1","unstructured":"Donaldson H. H.1924The Rat. Memoirs of the Wistar Institute of Anatomy and Biology. No. 6 Philadelphia pp.52\u201355."},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345680470012901"},{"key":"e_1_2_1_19_1","first-page":"26","article-title":"An electron microprobe investigation of the distribution of iron in rat incisor enamel","volume":"80","author":"Halse A.","year":"1972","journal-title":"Scand. J. dent, Res."},{"key":"e_1_2_1_20_1","first-page":"428","article-title":"Location and first appearance of rat incisor pigmentation","volume":"80","author":"Halse A.","year":"1972","journal-title":"Scand. J. dent. Res."},{"key":"e_1_2_1_21_1","first-page":"283","volume-title":"Advances in Fluorine Reserch and Dental Caries Prevention","author":"Helmcke J. G.","year":"1963"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(63)90044-X"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345650440012901"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345660450022301"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(70)90063-8"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0040-8166(74)90030-5"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-143-37426"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/10.3.269"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(68)90152-0"},{"key":"e_1_2_1_30_1","first-page":"48","article-title":"The effect of age on the proliferative activity of the periodontal membrane of the rat incisor","volume":"3","author":"Lavelle C. L. B.","year":"1968","journal-title":"J. Periodont. Res."},{"key":"e_1_2_1_31_1","first-page":"109","article-title":"The effect of age on the eruption rate of the incisor teeth of the rat","volume":"104","author":"Lavelle C. L. B.","year":"1969","journal-title":"J. Anat."},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345690480041901"},{"key":"e_1_2_1_33_1","first-page":"662","article-title":"Rat incisor pigmentation","volume":"74","author":"Lindemann G.","year":"1970","journal-title":"Tandlaegebladet"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345210030020101"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000142842"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02147630"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001060305"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091740310"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345720510043901"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00307201"},{"key":"e_1_2_1_41_1","first-page":"182","article-title":"Some theoretical aspects of radioautography","volume":"29","author":"Nadler N. J.","year":"1951","journal-title":"Cand. J. Med. Sci."},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1956.0077"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1959.0053"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1946.tb02619.x"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091330109"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(70)90068-7"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(62)90029-8"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(67)90023-4"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02059052"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1177\/22.4.217"},{"key":"e_1_2_1_51_1","first-page":"379","article-title":"Cell cycle and effects of Xirradiation on germ cells of rat incisors (Part I)","volume":"12","author":"Sasaki T.","year":"1965","journal-title":"Bull. Tokyo med. dent. Univ."},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.3109\/10520296509116427"},{"key":"e_1_2_1_53_1","first-page":"104","volume-title":"The Rat in Laboratory Investigation","author":"Schour I.","year":"1949"},{"key":"e_1_2_1_54_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345690480052401"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345660450055701"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1968.tb01910.x"},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345420210020901"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(74)90093-4"},{"key":"e_1_2_1_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001420403"},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345730520061201"},{"key":"e_1_2_1_61_1","first-page":"467","article-title":"Quantitative and radioautographic evidence for death of some ameloblasts immediately after completion of secretory activity","volume":"178","author":"Smith C. E.","year":"1974","journal-title":"Anat. Rec. (Proc.)"},{"key":"e_1_2_1_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001420402"},{"key":"e_1_2_1_63_1","first-page":"143","article-title":"The migration and renewal of tritium labelled cells in the developing enamel organs of rabbits","volume":"115","author":"Starkey W. E.","year":"1963","journal-title":"Brit. dent. J"},{"key":"e_1_2_1_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(59)90002-0"},{"key":"e_1_2_1_65_1","first-page":"137","article-title":"A study of the eruption rate of the mandibular rat incisors","volume":"30","author":"Sturman G. D.","year":"1957","journal-title":"Yale J. Biol. Med."},{"key":"e_1_2_1_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(70)90129-9"},{"key":"e_1_2_1_67_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345620410014701"},{"key":"e_1_2_1_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(71)90205-6"},{"key":"e_1_2_1_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401170109"},{"key":"e_1_2_1_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091610207"},{"key":"e_1_2_1_71_1","doi-asserted-by":"publisher","DOI":"10.1177\/15.9.542"},{"key":"e_1_2_1_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091790403"},{"key":"e_1_2_1_73_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345420210020701"},{"key":"e_1_2_1_74_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345670460031101"},{"key":"e_1_2_1_75_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345690480010401"},{"key":"e_1_2_1_76_1","first-page":"479","article-title":"Fibroblast cell kinetics in the peridontal ligament of the mouse","volume":"7","author":"Zajicek G.","year":"1974","journal-title":"Cell Tissue Kinet."},{"key":"e_1_2_1_77_1","first-page":"155","article-title":"Kinetics of the inner enamel epithelium in the adult rat incisor. I. Experimental results","volume":"4","author":"Zajicek G.","year":"1971","journal-title":"Cell Tissue Kinet."},{"key":"e_1_2_1_78_1","first-page":"163","article-title":"Kinetics of the inner enamel epithelium in the adult rat incisor. II. Computer model","volume":"4","author":"Zajicek G.","year":"1971","journal-title":"Cell Tissue Kinet."},{"key":"e_1_2_1_79_1","first-page":"35","article-title":"Kinetics of inner enamel epithelium in the adult rat incisor during accelerated eruption","volume":"5","author":"Zajicek G.","year":"1972","journal-title":"Cell Tissue Kinet."}],"container-title":["The Anatomical Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Far.1091830405","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.1091830405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T05:48:25Z","timestamp":1699768105000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ar.1091830405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,12]]},"references-count":78,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1975,12]]}},"alternative-id":["10.1002\/ar.1091830405"],"URL":"https:\/\/doi.org\/10.1002\/ar.1091830405","archive":["Portico"],"relation":{},"ISSN":["0003-276X","1097-0185"],"issn-type":[{"value":"0003-276X","type":"print"},{"value":"1097-0185","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,12]]}}}