{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T23:03:17Z","timestamp":1772751797174,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T00:00:00Z","timestamp":1107302400000},"content-version":"vor","delay-in-days":9955,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat. Rec."],"published-print":{"date-parts":[[1977,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In an attempt to localize the site of remodelling of collagen in the periodontal ligament of the continuously erupting mouse incisor a radioautographic and stereologic investigation was undertaken. Grain distributions in radioautographs for light microscopy were studied at various time intervals after administration of [<jats:sup>3<\/jats:sup>H]\u2010proline. The distribution of rough endoplasmic reticulum cisternae in fibroblasts and the incidence of collagen phagocytosis across the ligament were studied by means of stereologic methods at the electron microscopic level.<\/jats:p><jats:p>No significant differences were found in half lives of [<jats:sup>3<\/jats:sup>H]\u2010labelled substances among the various regions across the ligament. Roughendoplasmic reticulum cisternae within fibroblasts were distributed more or less uniformly throughout the entire width of the ligament. Analysis of the distribution of collagen phago\u2010cytosis, however, revealed that in the midregion of the ligament the amount of phagocytosed collagen was approximately four times as high as in the area adjcent to the tooth and about nine times as high as in the alveolar compartment.<\/jats:p><jats:p>It is concluded that synthesis and turnover of total protein occurs throughout the periodontal ligament but that remodelling of collagen predominantly takes place in an intermediate area of the ligament.<\/jats:p>","DOI":"10.1002\/ar.1091890308","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T12:05:05Z","timestamp":1109419505000},"page":"479-497","source":"Crossref","is-referenced-by-count":83,"title":["The site of remodelling of collagen in the periodontal ligament of the mouse incisor"],"prefix":"10.1002","volume":"189","author":[{"given":"W.","family":"Beertsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Everts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,2]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(73)90020-4"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(75)90134-X"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(74)90235-0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(75)90008-4"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(65)90077-4"},{"key":"e_1_2_1_7_1","first-page":"986","article-title":"Movement, during unimpeded eruption, of the position of cells, and of material incorporating tritiated proline, in the lingual periodontal membrane of the mandibular incisors of adult male mice","volume":"47","author":"Chiba M.","year":"1968","journal-title":"J. Dent. Res."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1976.47.7.380"},{"key":"e_1_2_1_9_1","unstructured":"Guis M. B.1976Collagen in the Periodontal Ligament of the Continuously Erupting Guinea Pig Incisors. A Biochemical Study on Its Presence Properties and Metabolism. Thesis University of Utrecht."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1973.tb00767.x"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(67)90199-9"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1971.tb00598.x"},{"key":"e_1_2_1_13_1","first-page":"176","volume-title":"The Biology of the Periodontium","author":"Melcher A. H.","year":"1969"},{"key":"e_1_2_1_14_1","first-page":"107","volume-title":"The Mechanisms of Tooth Support. A Symposium, 1965","author":"Ramos A. B.","year":"1967"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1976.tb00057.x"},{"key":"e_1_2_1_16_1","volume-title":"Techniques in Autoradiography","author":"Rogers A. W.","year":"1967"},{"key":"e_1_2_1_17_1","first-page":"580","article-title":"Bau und Funktion des Fixationsapparates des Meerschweinchenmolaren","volume":"23","author":"Sicher H.","year":"1923","journal-title":"Z. Stomatol."},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345420210020901"},{"key":"e_1_2_1_19_1","unstructured":"Slootweg R. N.1976Changes of Collagen and Non\u2010colla\u2010genous Proteins in the Periodontal Ligament during Acceleration of the Eruption. A Biochemical and Histo\u2010logical Investigation in Different Sectors of the Periodontal Ligament in the Guinea Pig Incisor. Thesis University of Utrecht."},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091820102"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9416(76)90194-9"},{"key":"e_1_2_1_22_1","first-page":"102","volume-title":"The Mechanisms of Tooth Support. A Symposium,1965","author":"Thomas N. 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