{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:37:32Z","timestamp":1790937452573,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,1,26]],"date-time":"2005-01-26T00:00:00Z","timestamp":1106697600000},"content-version":"vor","delay-in-days":9675,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat. Rec."],"published-print":{"date-parts":[[1978,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Circadian rhythms in DNA synthesis are described for the tongue epithelium, five different regions of the alimentary canal (gut) \u2013esophagus, stomach, duodenum, jejunum and rectum\u2013 and bone marrow in a group of BDF<jats:sup>1<\/jats:sup> male mice. A circadian rhythm is also described for the mitotic index in the corneal epithelium in the same mice. The data document for the first time in the same animals the dramatic variation in cell division encountered from one region of the gut to another. This variation is seen in the amplitudes of the rhythms as well as in the over\u2010all 24\u2010hour means. On the contrary, the phasings of the rhythms in the different regions of the gut are remarkably similar. In this study, where the mice were standardized to 12 hours of light (0600\u20101800) alternating with 12 hours of darkness, the peak of the DNA\u2010synthesis rhythm occurred around the time of transition from dark to light, and the trough around the time of transition from light to dark. The implications of these findings, and those of others, to the study of cell kinetics and to cancer chemotherapy are discussed.<\/jats:p>","DOI":"10.1002\/ar.1091910407","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T11:54:42Z","timestamp":1109418882000},"page":"479-486","source":"Crossref","is-referenced-by-count":121,"title":["Circadian variation in cell division of the mouse alimentary tract, bone marrow and corneal epithelium"],"prefix":"10.1002","volume":"191","author":[{"given":"Lawrence E.","family":"Scheving","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Robert","family":"Burns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Pauly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tien\u2010Hu","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,1,26]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000141580"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02477020"},{"key":"e_1_2_1_4_1","first-page":"61","article-title":"Circadian influence on the wave form of the frequency of labeled mitoses in the mouse corneal epithelium","volume":"8","author":"Burns E. R.","year":"1975","journal-title":"Cell Tissue Kinet."},{"key":"e_1_2_1_5_1","first-page":"1538","article-title":"Effect of altered lighting regimens, time\u2010 limited feeding, and presence of Ehrlich ascites carcinoma on the circadian rhythm in DNA synthesis of mouse spleen","volume":"36","author":"Burns E. R.","year":"1976","journal-title":"Cancer Research"},{"key":"e_1_2_1_6_1","first-page":"960","article-title":"Mitotic cycle of epithelium cells in cornea in mice, by means of thymidine tagged with tritium","volume":"149","author":"Chumak M. G.","year":"1963","journal-title":"Dokl. Akad. Nauk. SSSR"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.177.4043.80"},{"key":"e_1_2_1_8_1","first-page":"346","article-title":"Mitotic activity in the gastric glands of the rat","volume":"112","author":"Hunt T. E.","year":"1952","journal-title":"Anat. Rec."},{"key":"e_1_2_1_9_1","first-page":"316","article-title":"Experimental chronotherapy with ara\u2010C: comparison of murine ara\u2010C tolerance on differently timed treatment schedules","volume":"1","author":"Kuhl J. F. W.","year":"1974","journal-title":"Chronobiologia"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091000306"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000141150"},{"key":"e_1_2_1_12_1","first-page":"262","article-title":"The nucleic acids of plant tissues. I. The nucleic acid","volume":"25","author":"Ogur M.","year":"1970","journal-title":"Arch. Biochem."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/199863a0"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(59)90063-1"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.32.3.677"},{"key":"e_1_2_1_16_1","first-page":"269","article-title":"Cellular mechanisms involving biorhythms with emphasis on those rhythms associated with the S and M stages of the cell cycle","volume":"1","author":"Scheving L. E.","year":"1973","journal-title":"Int. J. Chronobiology"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001350302"},{"key":"e_1_2_1_18_1","first-page":"1063","volume-title":"Can chronobiology be ignored when considering the cancer problem? In: Proceedings of the Third International Symposium on Detection and Prevention of Cancer","author":"Scheving L. E.","year":"1977"},{"key":"e_1_2_1_19_1","unstructured":"Scheving L. E. E. R.BurnsandJ. E.Pauly1977bCoincidence in timing between the S and M stages of the cell cycle in liver parenchymal cells in mice bearing an 8\u2010day Ehrlich ascites tumor (EAT). In: Proceedings of the XIIth International Conference of Chronobiology Washington D. C. August 10\u201013 1975."},{"key":"e_1_2_1_20_1","first-page":"427","volume-title":"Casa Editrice \u201cIl Ponte\u201d"},{"key":"e_1_2_1_21_1","first-page":"3648","article-title":"Survival and cure of leukemic mice after optimization of treatment with cyclophosphamide and arabinosyl cytosine","volume":"37","author":"Scheving L. E.","year":"1977","journal-title":"Cancer Res."},{"key":"e_1_2_1_22_1","first-page":"1113","article-title":"Close reproduction by different laboratories of characteristics of circadian rhythm to 1\u2010\u03b2\u2010D\u2010arabinofuranosylcytosine tolerance by mice","volume":"36","author":"Scheving L. E.","year":"1975","journal-title":"Cancer Res."},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(69)90126-8"},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/BF02889385","article-title":"Circadian rhythms in hairless mouse epidermal DNA synthesis as measured by double labeling with H3\u2010thymidine","volume":"11","author":"Tvermyr E. M.","year":"1972","journal-title":"Virchows Arch., Abt. B. Zellpath."}],"container-title":["The Anatomical Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Far.1091910407","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.1091910407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T12:09:11Z","timestamp":1699790951000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ar.1091910407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,8]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1978,8]]}},"alternative-id":["10.1002\/ar.1091910407"],"URL":"https:\/\/doi.org\/10.1002\/ar.1091910407","archive":["Portico"],"relation":{},"ISSN":["0003-276X","1097-0185"],"issn-type":[{"value":"0003-276X","type":"print"},{"value":"1097-0185","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,8]]}}}