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In addition, some hepatocytes exhibit nuclear lipid pseudo\u2010 and true inclusions. Other prominent features of hepatocytes after lithogenic diet include segregation of nucleolar granular and fibrillar material. Accumulation of considerable collagen in extracellular spaces is also noted. Observations suggest changes induced by the cholesterol diet are comparable to cytologic alterations seen in spontaneous and drug induced hepatic tumors, as well as to more general \u201cfatty metamorphosis\u201d of the liver.<\/jats:p>","DOI":"10.1002\/ar.1091940108","type":"journal-article","created":{"date-parts":[[2005,2,27]],"date-time":"2005-02-27T00:09:52Z","timestamp":1109462992000},"page":"113-123","source":"Crossref","is-referenced-by-count":2,"title":["Alterations in hepatocytes of mice fed a gallstone\u2010inducing diet: Occurrence of nuclear and cytoplasmic lipids"],"prefix":"10.1002","volume":"194","author":[{"given":"L. 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