{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T06:40:48Z","timestamp":1744180848439},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,1,26]],"date-time":"2005-01-26T00:00:00Z","timestamp":1106697600000},"content-version":"vor","delay-in-days":9249,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat. Rec."],"published-print":{"date-parts":[[1979,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lymphocyte production by mesenteric lymph nodes of normal young pigs was studied by intranodal injections of either tritiated thymidine or tritiated deoxycytidine as DNA precursors. One or two days after selective labeling of the mesenteric lymph nodes the relative and absolute number of lymphocytes derived from mesenteric lymph nodes were determined autoradiographically in the following organs: mesenteric, cervical and inguinal lymph nodes, spleen, thymus, bone marrow, peyer'spatches, tonsil, different regions of the gut, lung and liver. The overall cell production of mesenteric lymph nodes, as derived from the sum of all labeled cells one day after labeling, was estimated to be about 7 \u00d7 10<jats:sup>9<\/jats:sup> lymphocytes. Up to 40% of all newly formed lymphocytes had already left the lymph nodes within one day and were found in all organs studied. There was a preferential homing to the mucosa of the small intestine, but a considerable number migratedto the spleen and even to the thymus and bone marrow. In lymphoid organs all labeled cells were small and medium\u2010sized lymphocytes one and two days after labeling. In cervical lymph nodes, spleen, tonsil and peyer's patches the relative distribution to T and B cell areas was determined. There was an obvious preference of newly formed lymph node cells to home to T cell areas. The differences of labeling between thymidine or deoxycytidine were surprisingly low.<\/jats:p>","DOI":"10.1002\/ar.1091950208","type":"journal-article","created":{"date-parts":[[2005,2,27]],"date-time":"2005-02-27T00:14:53Z","timestamp":1109463293000},"page":"341-355","source":"Crossref","is-referenced-by-count":13,"title":["Selective labeling of mesenteric lymph nodes: Cell production and emigration ofnewly formed lymphocytes to other organs"],"prefix":"10.1002","volume":"195","author":[{"given":"R.","family":"Pabst","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Trepel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,1,26]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"167","article-title":"Preferential labeling of rat lymphocytes with a rapid rate of turnover by tritiated deoxycytidine","volume":"9","author":"Amano M.","year":"1976","journal-title":"Cell Tissue Kinet."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091680202"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-124-31675"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-9011-8_16"},{"key":"e_1_2_1_6_1","first-page":"1","article-title":"Lymphocyte migration and immune responses","volume":"19","author":"Ford W. 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