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At day 53, numerous cupshaped mitochondria appeared; these often nested one inside the other. From this day onward, the mitochondria showed a tendency towards increasing size. By day 82, some had a diameter greater than 8 \u03bcm. These and other, smaller mitochondria often contained extremely prominent matrix granules. The production by riboflavin\u2010deficiency of giant mitochondria in the rat liver appears to be unrelated to their capacity to carry out oxidative metabolism.<\/jats:p>","DOI":"10.1002\/ar.1091960209","type":"journal-article","created":{"date-parts":[[2005,2,27]],"date-time":"2005-02-27T00:06:41Z","timestamp":1109462801000},"page":"183-190","source":"Crossref","is-referenced-by-count":20,"title":["Ultrastructural effects of riboflavin deficiency on rat hepatic mitochondria"],"prefix":"10.1002","volume":"196","author":[{"given":"Bernard","family":"Tandler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles L.","family":"Hoppel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.22.3.704"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"4164","DOI":"10.1016\/S0021-9258(18)50710-9","article-title":"Riboflavin and rat hepatic structure and function. 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