{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:02:45Z","timestamp":1760644965902},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,1,26]],"date-time":"2005-01-26T00:00:00Z","timestamp":1106697600000},"content-version":"vor","delay-in-days":8579,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat. Rec."],"published-print":{"date-parts":[[1981,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The nature of the trophic response of the mouse submandibular gland to thyroxine (T4) was examined. Adult female Swiss\u2010 Webster mice were given daily subcutaneous injections of T4 (1 \u03bcg\/gm body weight) for two or four days; two injections of tritiated thymidine (3H\u2010 TdR) were given 24 and 29 hours after the last injection of hormone, and the mice were killed one hour after the last injection of 3H\u2010 TdR. One gland was analyzed chemically for DNA content and for incorporation of 3H\u2010 TdR, while the other was used to prepare autoradiograms. The cellular composition of each gland was analyzed by counting 1000 nuclei, and the frequency and labelling index (LI) of six cell types were established. A rise in specific activity of DNA and a fall in its concentration were seen in response to T4. The LI for the entire gland more than doubled. The LIs and frequencies of granular convoluted tubule and granular intercalated duct cells were increased more than those of acinar and nongranular intercalated duct cells; striated and excretory duct cells were not affected. It is concluded that the enlargement of the submandibular gland of the mouse caused by T4 is due to both hyperplastic and hypertrophic effects.<\/jats:p>","DOI":"10.1002\/ar.1092000407","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T23:47:17Z","timestamp":1109461637000},"page":"443-446","source":"Crossref","is-referenced-by-count":12,"title":["Hypertrophic and hyperplastic effects of thyroxine on the submandibular gland of the mouse"],"prefix":"10.1002","volume":"200","author":[{"given":"E. W.","family":"Gresik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"van der Noen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Barka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,1,26]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(80)90183-4"},{"key":"e_1_2_1_3_1","first-page":"1611","article-title":"Action de la thyroidectomie et des injections de thyroxine sur la glande sous\u2010maxillaire de la Souris albinos","volume":"230","author":"Arvy L.","year":"1950","journal-title":"C. R. Acad. Sci."},{"key":"e_1_2_1_4_1","first-page":"2333","article-title":"Action des injections de thyroxine et de folliculine sur la glande sous\u2010maxillaire de la Souris femelle","volume":"230","author":"Arvy L.","year":"1950","journal-title":"C. R. Acad. Sci."},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(65)90040-6"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(65)90214-4"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(67)90382-5"},{"key":"e_1_2_1_8_1","first-page":"226A","article-title":"Mitogenic effect of testosterone on the submandibular gland of castrated male mice","volume":"196","author":"Bruschi L.","year":"1980","journal-title":"Anat. Rec. (Abstr.)"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(08)60101-1"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001590206"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","unstructured":"Gresik E. I.Schenkein H.van der Noen andT.Barka(1980)Hormonal regulation of epidermal growth factor and protease in the submandibular gland of the adult mouse. Endocrinology (in press).","DOI":"10.1210\/endo-109-3-924"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/physzool.25.3.30152226"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.0830429"},{"key":"e_1_2_1_14_1","first-page":"400","article-title":"Control hormonal de la glande sous\u2010maxillaire de la Souris","volume":"94","author":"Raynaud J.","year":"1960","journal-title":"Bull. Biol."},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2787(79)90230-2"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)90979-8"}],"container-title":["The Anatomical Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Far.1092000407","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.1092000407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T05:53:32Z","timestamp":1699768412000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ar.1092000407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,8]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1981,8]]}},"alternative-id":["10.1002\/ar.1092000407"],"URL":"https:\/\/doi.org\/10.1002\/ar.1092000407","archive":["Portico"],"relation":{},"ISSN":["0003-276X","1097-0185"],"issn-type":[{"value":"0003-276X","type":"print"},{"value":"1097-0185","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,8]]}}}