{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:39:33Z","timestamp":1761100773925},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,1,26]],"date-time":"2005-01-26T00:00:00Z","timestamp":1106697600000},"content-version":"vor","delay-in-days":8579,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat. Rec."],"published-print":{"date-parts":[[1981,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>C\u2010cell complexes are special cell groups consisting of a mass of C\u2010cells associated with other epithelial elements and cysts. They are remnants of ultimobranchial bodies retaining fetal characteristics. In the C\u2010cell complexes there are follicular cells in various stages of differentiation, i.e., the cell clusters not yet organized into follicles, primordial follicles with small lumens and comparatively enlarged follicles storing plentiful amounts of colloid. They have a morphology similar to follicular cells of fetal thyroid glands and react to antiserum to 19S thyroglobulin. In order to determine whether or not the follicles in these complexes have the ability to incorporate radioiodine, autoradiography after a single injection of <jats:sup>125<\/jats:sup>I was combined with immunoperoxidase staining using specific anti\u2010calcitonin, anti\u2010C\u2010thyroglobulin, and anti\u201019S thyroglobulin antisera. The 19S\u2010positive cells not yet organized into follicles did not take up radioiodine. Primordial follicles showed a heavy accumulation of silver grains over their follicular lumens storing new 19S thyroglobulin as colloid. Comparatively enlarged follicles revealed a strong autoradiographic reaction and their labeling patterns were identical with those of typical thyroid follicles. These results confirm that the follicles in C\u2010cell complexes, as well as thyroid follicles, can incorporate radioiodine and are related to thyroid hormone synthesis. That is, functional thyroid follicles can arise from the ultimobranchial bodies.<\/jats:p>","DOI":"10.1002\/ar.1092000409","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T23:47:17Z","timestamp":1109461637000},"page":"461-470","source":"Crossref","is-referenced-by-count":16,"title":["Uptake of radioiodine in follicles of dog C\u2010cell complexes studied by autoradiograph and immunoperoxidase staining"],"prefix":"10.1002","volume":"200","author":[{"given":"Yoko","family":"Kameda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,1,26]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(74)90111-8"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1679\/aohc1950.33.115"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1679\/aohc1950.36.89"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1679\/aohc1950.37.225"},{"key":"e_1_2_1_6_1","first-page":"155","volume-title":"Chromaffin, Enterochromaffin and Related Cells","author":"Kameda Y.","year":"1976"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1679\/aohc1950.40.Supplement_133"},{"key":"e_1_2_1_8_1","unstructured":"Kameda Y.(1981a)Studies on C cell\u2010immunoreactive thyroglobulin: Age difference reduction and trypsin digestion. Biochim. Biophys. Acta In press."},{"key":"e_1_2_1_9_1","unstructured":"Kameda Y.(1981b)Studies on C cell\u2010immunoreactive thyroglobulin: Uptake of125I and iodine content. In press."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197912)44:6<2071::AID-CNCR2820440618>3.0.CO;2-O"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-102-6-1702"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2795(79)90027-8"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00495751"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00233873"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00233874"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00237970"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-74-3-333"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-87-5-1000"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(66)90481-8"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-406X(68)90753-6"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-6480(72)90245-6"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1016\/S0021-9258(18)97269-8","article-title":"27S thyroid iodoprotein","volume":"240","author":"Salvatore G.","year":"1965","journal-title":"J. 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