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Tenotomized muscle also was characterized by the presence of N\u2010line\u2010like bands and I\u2010Z\u2010I brushes. CAF digestion removed the electron\u2010dense covering material from Z\u2010rods and revealed a backbone of actin filaments. The origin of Z\u2010rods, their structural similarity to Z\u2010lines in longitudinal and cross section, and their susceptibility to CAF indicate that Z\u2010rods are directly related to native Z\u2010lines and are probably lateral polymers of a basic Z\u2010line unit.<\/jats:p><jats:p>The regular square net alignment (22 nm) of I\u2010filaments (actin) in cross sections of I\u2010Z\u2010I brushes which contain no N\u2010lines suggests that the I\u2010square net arrangement near the Z\u2010line is determined by Z\u2010filament\u2010actin filament interaction rather than by the N\u2010line or other factors.<\/jats:p><jats:p>The results suggest that I\u2010filaments (actin) penetrate the mammalian Z\u2010line and are Z\u2010line constituents and that the width of Z\u2010lines and the length of Z\u2010rods are determined by the amount of overlap of actin filaments. The perpendicular periodicity of Z\u2010rods and the zigzag\u2010oblique arrowheadlike appearance seen in longitudinal section of Z\u2010lines are attributed to \u03b1\u2010actinin.<\/jats:p>","DOI":"10.1002\/ar.1092060402","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T10:10:23Z","timestamp":1109412623000},"page":"345-362","source":"Crossref","is-referenced-by-count":20,"title":["Properties of soleus muscle Z\u2010lines and induced Z\u2010line analogs revealed by dissection with Ca<sup>2+<\/sup>\u2010activated neutral protease"],"prefix":"10.1002","volume":"206","author":[{"given":"Mamoru","family":"Yamaguchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M.","family":"Robson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marvin H.","family":"Stromer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal R.","family":"Cholvin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Izumimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,1,26]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.15.4.371"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(78)90183-1"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.52.2.367"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.94.3.565"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4800(70)90093-6"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"4036","DOI":"10.1016\/S0021-9258(17)34795-6","article-title":"Filamin\u2010actin interaction. 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