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In the present paper, K<jats:sup>+<\/jats:sup>\u2010NPPase activity was cytochemically studied by the method of Mayahara et al. (1980) in gastric glands of birds, amphibia, and mammals, either in the resting state induced by cimetidine or after stimulation of HC1 secretion by histamine.<\/jats:p><jats:p>The gastric K<jats:sup>+<\/jats:sup>\u2010NPPase cytochemical reaction was localized only in oxyntic cells of the gastric mucosa in the three species tested.<\/jats:p><jats:p>The subcellular distribution of the K<jats:sup>+<\/jats:sup>\u2010NPPase reaction product drastically changes with the secretory state of HC1. In resting cells, the K<jats:sup>+<\/jats:sup>\u2010NPPase staining is associated with the membranes of the endocellular tubular system while in HC1\u2010secreting cells, it is associated with the plasma membrane of the elaborate secretory surface characteristic of this functional state. The above results demonstrate that the same enzymatic activity, which is associated with the gastric proton pump, is present in both membranous systems of the oxyntic cell secretory pole. This fact supports the proposal that the tubular system represents a membrane reserve that inserts the proton pump into the luminal plasma membrane in vertebrate oxyntic cells under the action of HC1 secretagogues.<\/jats:p>","DOI":"10.1002\/ar.1092100406","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T23:16:46Z","timestamp":1109459806000},"page":"583-596","source":"Crossref","is-referenced-by-count":7,"title":["Redistribution of gastric K<sup>+<\/sup>\u2010NPPase in vertebrate oxyntic cells in relation to hydrochloric acid secretion: A cytochemical study"],"prefix":"10.1002","volume":"210","author":[{"given":"Cecilia S.","family":"Koenig","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,1,26]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"3088","article-title":"Sodium\u2010potassium\u2010activated adenosine triphosphatase VII: Concurrent inhibition of Na++K+ adenosinetriphosphatase and activation of K+\u2010nitrophenyl phosphatase activities","volume":"247","author":"Alberts R. 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