{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T06:31:36Z","timestamp":1777703496472,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,1,26]],"date-time":"2005-01-26T00:00:00Z","timestamp":1106697600000},"content-version":"vor","delay-in-days":6449,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat. Rec."],"published-print":{"date-parts":[[1987,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During enamel maturation in rodents, an iron\u2010containing pigment is deposited into the surface layer of the enamel. Maturation zone ameloblasts presumably are responsible for this deposition. The presence of large amounts of ferritin in the cytoplasm of these cells suggests that they receive iron, presumably from circulating transferrin. An in vivo radioautographic binding assay using iodinated transferrin was used to determine if indeed maturation ameloblasts possess transferrin receptors at their cell surfaces. Experimental rats received systemic injections of labeled transferrin while control rats received injections of labeled transferrin plus a large excess of unlabeled transferrin in order to complete with the labeled transferrin for available specific receptors. Light microscope radioautography showed that ruffle\u2010ended ameloblasts (RAs) of the enamel maturation zone had a high density of specific receptors for transferrin relative to smooth\u2010ended ameloblasts (SAs). Electron microscopy and energy\u2010dispersive X\u2010ray spectroscopy confirmed the presence of ferritin and iron, respectively, within these cells. It is postulated that the iron responsible for enamel pigmentation is transported by transferrin to maturation ameloblasts and is bound to specific transferrin receptors found mostly on RAs and that the modulation of these cells into SAs results in a loss of most of these receptors.<\/jats:p>","DOI":"10.1002\/ar.1092180205","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T22:44:26Z","timestamp":1109457866000},"page":"123-127","source":"Crossref","is-referenced-by-count":24,"title":["Specific binding sites for transferrin on ameloblasts of the enamel maturation zone in the rat incisor"],"prefix":"10.1002","volume":"218","author":[{"given":"M. D.","family":"McKee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Zerounian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Martineau\u2010Doiz\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Warshawsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,1,26]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1050260103"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.11.5051"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(61)90015-6"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(60)90226-5"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3002(54)90376-5"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.36.5.539"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0021-9258(17)41274-9","article-title":"Ferritin: Increase of protein apoferritin in gastrointestinal mucosa as direct response to iron feeding","volume":"164","author":"Granick S.","year":"1946","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1951.31.4.489"},{"key":"e_1_2_1_10_1","first-page":"91","article-title":"Ferritin. II. Apoferritin of horse spleen","volume":"147","author":"Granick S.","year":"1943","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_11_1","first-page":"26","article-title":"An electron microscope investigation of the distribution of iron in incisor enamel","volume":"80","author":"Halse H.","year":"1972","journal-title":"Scand. J. Dent. Res."},{"key":"e_1_2_1_12_1","first-page":"428","article-title":"Location and first appearance of rat incisor pigmentation","volume":"80","author":"Halse H.","year":"1972","journal-title":"Scand. J. Dent. Res."},{"key":"e_1_2_1_13_1","first-page":"47","article-title":"Incorporation of iron in rat incisor enamel","volume":"82","author":"Halse H.","year":"1974","journal-title":"Scand. J. Dent. Res."},{"key":"e_1_2_1_14_1","first-page":"392","volume-title":"Review of Physiological Chemistry","author":"Harper H. A.","year":"1971"},{"key":"e_1_2_1_15_1","first-page":"31","volume-title":"The Red Cell","author":"Harris J. W.","year":"1963"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/194495a0"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(68)90052-X"},{"key":"e_1_2_1_18_1","first-page":"45","article-title":"Ameloblast modulation in the maturation zone of the rat incisor enamel organ. A light and electron microscopic study","volume":"124","author":"Josephsen K.","year":"1977","journal-title":"J. Anat."},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(70)90063-8"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001690308"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(60)80017-2"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"4715","DOI":"10.1016\/S0021-9258(18)32481-5","article-title":"Receptor mediated endocytosis of transferrin in K562 cells","volume":"258","author":"Klausner R. D.","year":"1983","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/10.3.269"},{"key":"e_1_2_1_24_1","first-page":"662","article-title":"Rat incisor pigmentation","volume":"74","author":"Lindemann G.","year":"1970","journal-title":"Tandlaegebladet"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.37.2.131"},{"key":"e_1_2_1_26_1","first-page":"256","volume-title":"Tooth Enamel IV","author":"Ogura H.","year":"1984"},{"key":"e_1_2_1_27_1","first-page":"443","article-title":"Studies on incisor pigmentation in relation to liver iron and blood picture of the white rat. V. Histochemical demonstration of the embedding of the pigment in the enamel","volume":"55","author":"Pindborg J. J.","year":"1947","journal-title":"Odont. Tidsk."},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1946.tb02619.x"},{"key":"e_1_2_1_29_1","first-page":"235","article-title":"Iron metabolism and kinetics","volume":"3","author":"Pollycove M.","year":"1966","journal-title":"Semin. Hematol."},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105841"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091330109"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.9.4.825"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(86)90155-X"},{"key":"e_1_2_1_34_1","volume-title":"Polarizing Microscopy of Dental Tissues","author":"Schmidt W. J.","year":"1971"},{"key":"e_1_2_1_35_1","first-page":"104","volume-title":"The Rat in Laboratory Investigation","author":"Schour I.","year":"1949"},{"key":"e_1_2_1_36_1","first-page":"131","article-title":"Structure and function of the transferrin receptor","volume":"8","author":"Seligman P. A.","year":"1983","journal-title":"Prog. Hematol."},{"key":"e_1_2_1_37_1","first-page":"88","article-title":"The ultrastructural localization of iron in rat incisor enamel","volume":"83","author":"Selvig K. A.","year":"1975","journal-title":"Scand. J. Dent. Res."},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-110-27426"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.7.4515"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02409412"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.5.3039"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/15.9.542"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.42.1.45-66.1978"}],"container-title":["The Anatomical Record"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Far.1092180205","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Far.1092180205","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.1092180205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T19:29:11Z","timestamp":1697830151000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ar.1092180205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,6]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1987,6]]}},"alternative-id":["10.1002\/ar.1092180205"],"URL":"https:\/\/doi.org\/10.1002\/ar.1092180205","archive":["Portico"],"relation":{},"ISSN":["0003-276X","1097-0185"],"issn-type":[{"value":"0003-276X","type":"print"},{"value":"1097-0185","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,6]]}}}