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Rats were killed at 7, 14, or 21 days following sympathectomy. Mandibular periosteal and endosteal surfaces were analyzed by fluorochrome morphometry. Osteoclasts were identified by acid phosphatase staining, and incisor and molar root sockets were analyzed morphometrically. Following sympathectomy, periosteal and endosteal apposition as well as the rate of mineralization were significantly lower. At the same time, a significant increase in the number of osteoclasts per socket as well as in active and inactive bone resorption surfaces was also seen. All parameters, however, returned to normal values 2\u20133 weeks after sympathectomy. The data provide the first direct quantitative evidence that sympathetic neurons modulate bone resorption and bone remodeling in vivo.<\/jats:p>","DOI":"10.1002\/ar.1092190107","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T22:46:59Z","timestamp":1109458019000},"page":"32-38","source":"Crossref","is-referenced-by-count":83,"title":["Effect of surgical sympathectomy on bone remodeling at rat incisor and molar root sockets"],"prefix":"10.1002","volume":"219","author":[{"given":"H. S.","family":"Sandhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. S.","family":"Herskovits","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. 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