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In many animal species including dogs, cats, cattle, monkeys, rats, and rabbits, almost all C cells revealed an intense immunoreactivity for CGRP; the cytoplasm of C cells was filled with reaction products for CGRP. In these animal species, calcitonin and CGRP coexisted in the C cells. However, in some species including pigs, mice, hamsters, and guinea pigs, the CGRP immunoreactivity of C cells was weak or negative. It was concluded that there was a considerable variation in CGRP immunoreactivity of C cells from species to species. In rabbits and guinea pigs, almost all C cells were also intensely immunoreactive to antisomatostatin antiserum, whereas in other animal species including dogs, cats, cattle, monkeys, rats, pigs, mice, and hamsters only a few C cells were immunoreactive to somatostatin. Three peptides\u2013calcitonin, somatostatin, and CGRP\u2014are synthesized alone in rabbit C cells. Thus, there was no relation between CGRP and somatostatin concerning the existence of both peptides in thyroid C cells.<\/jats:p>","DOI":"10.1002\/ar.1092190214","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T22:47:38Z","timestamp":1109458058000},"page":"204-212","source":"Crossref","is-referenced-by-count":29,"title":["Localization of immunoreactive calcitonin gene\u2010related peptide in thyroid C cells from various mammalian species"],"prefix":"10.1002","volume":"219","author":[{"given":"Yoko","family":"Kameda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,8]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/298240a0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/313054a0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00236889"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.12.7801"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.493987"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.04-12-03101.1984"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-119-5-2313"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(76)90008-7"},{"key":"e_1_2_1_10_1","first-page":"97","article-title":"Distribution of C\u2010cells in parathyroid gland IV and thymus IV of different mammals studied by immunoperoxidase method using anti\u2010calcitonin and anti\u2010C\u2010thyroglobulin antisera","volume":"7","author":"Kameda Y.","year":"1981","journal-title":"Kawasaki Med. 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