{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T22:05:37Z","timestamp":1757541937974},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,2,8]],"date-time":"2005-02-08T00:00:00Z","timestamp":1107820800000},"content-version":"vor","delay-in-days":5974,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat. Rec."],"published-print":{"date-parts":[[1988,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mouse iodinated epidermal growth factor (EGF) was localized by light and electron microscopic radioautography in basal cells of oral epithelium, papillary cells of the enamel organ, periodontal ligament fibroblasts, preodontoblast precursor cells, and preosteoblasts of the alveolar bone of 13\u2010day\u2010old Sprague\u2010Dawley rats. The specificity of binding in these cells was suggested by an observed reduction of about 90% in the labeling when excess unlabeled EGF was injected along with the <jats:sup>125<\/jats:sup>I\u2010EGF. In contrast, fully differentiated cells, such as ameloblasts, odontoblasts, and osteoblasts, were only poorly labeled. Quantitative analysis of the light microscopic radioautographs revealed that the papillary cells had the highest level of labeling (5.5 grains per 100 \u03bcm<jats:sup>2<\/jats:sup> of cell area). The significance of the rather high labeling of the preosteoblasts of the alveolar bone and the fibroblasts of the periodontal ligament is unknown. However, the well\u2010known effect of EGF in producing precocious eruption of teeth may be a consequence of an effect on these two cell types.<\/jats:p>","DOI":"10.1002\/ar.1092220212","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T22:41:01Z","timestamp":1109457661000},"page":"191-200","source":"Crossref","is-referenced-by-count":27,"title":["Radioautographic demonstration of receptors for epidermal growth factor in various cells of the oral cavity"],"prefix":"10.1002","volume":"222","author":[{"given":"Moon\u2010Il","family":"Cho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Lin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philias R.","family":"Garant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,8]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.87.2.360"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(82)80022-1"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1242\/jcs.58.1.125","article-title":"Association between tension and orientation of periodontal ligament fibroblasts and exogenous collagen fibres in collagen gel in vitro","volume":"58","author":"Bellows C. G.","year":"1982","journal-title":"J. Cell Sci"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.11.5051"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"4058","DOI":"10.1016\/S0021-9258(17)34798-1","article-title":"Intracellular polypeptide hormone receptors. The demonstration of specific binding sites for insulin and human growth hormone in Golgi fractions isolated from the liver of female rats","volume":"253","author":"Bergeron J. J. M.","year":"1978","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.15.2.173"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.71.1.159"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.48.070179.001205"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091990302"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092010402"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)83739-0"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(08)60107-2"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.93.1.82"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80527-8"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.81.2.382"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/194495a0"},{"key":"e_1_2_1_18_1","first-page":"137A","article-title":"A formaldehyde\u2010glutaraldehyde fixative of high osmollity for use in electron microscopy","volume":"27","author":"Karnovsky M. J.","year":"1965","journal-title":"J. Cell Biol."},{"key":"e_1_2_1_19_1","first-page":"389","volume-title":"Development of Diseases of Cartilage and Bone Matrix","author":"Martineau\u2010Doize B.","year":"1987"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(86)90042-7"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12264708"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12285389"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(87)90117-5"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.94.2.379"},{"key":"e_1_2_1_25_1","first-page":"270","volume-title":"Oral Histology, Development, Structure and Function","author":"Ten Cate A. R.","year":"1980"},{"key":"e_1_2_1_26_1","first-page":"371","volume-title":"Organ's Oral Histology and Embryology","author":"Ten Cate A. R.","year":"1980"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1987.tb01609.x"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/9.1.24"},{"key":"e_1_2_1_29_1","first-page":"947","article-title":"The role of collagen maturation in alveolar bone growth and tooth eruption","volume":"43","author":"Thomas N. R.","year":"1964","journal-title":"J. Dent. Res."},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.85.3.682"}],"container-title":["The Anatomical Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Far.1092220212","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.1092220212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T08:07:23Z","timestamp":1698048443000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ar.1092220212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,10]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1988,10]]}},"alternative-id":["10.1002\/ar.1092220212"],"URL":"https:\/\/doi.org\/10.1002\/ar.1092220212","archive":["Portico"],"relation":{},"ISSN":["0003-276X","1097-0185"],"issn-type":[{"value":"0003-276X","type":"print"},{"value":"1097-0185","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,10]]}}}