{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:43:11Z","timestamp":1791902591026,"version":"4.3.4"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,1,26]],"date-time":"2005-01-26T00:00:00Z","timestamp":1106697600000},"content-version":"vor","delay-in-days":5930,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat. Rec."],"published-print":{"date-parts":[[1988,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have studied the response of nerve fibers containing calcitonin gene\u2010related peptide immunoreactivity (CGRP\u2010IR) to inflammation using a rat dental experimental system. Inflammation was induced by drilling tooth cusps to create pulpal exposures; the induced pulpitis and subsequent periapical lesions were studied 1\u201335 days later using standard CGRP immunohistochemistry and the avidinbiotin peroxidase method. The injury and resulting inflammation caused a disruption of CGRP\u2010IR nerve fiber location and arborization that varied depending on whether the initial injury was limited to the pulp tip or extended throughout the pulp horn. At shorter survival periods (24 hr, 3 days) nerve fibers were either decreased or bundled into the center of the pulp with sprouting along the wound border. At 6 days necrosis and acute inflammation had advanced to varying degrees, and CGRP\u2010IR fibers were extensively sprouted in the surviving pulp; the pulp also stained specifically for CGRP within 1\u20132 mm of the infalmed tissue at 6 days. At 35 days, we found total pulp necrosis in most teeth and the development of periapical bone loss, granulomatous tissue, and periapical abscesses. There was also an extensive increase in CGRP\u2010IR nerve fibers in the tissues surrounding sites of severe periodontal inflammation and necrosis. In some cases, macrophage\u2010like cells staining specifically for CGRP were near the abscesses. The results show important interactions between peptidergic nerve fibers and inflammatory cells, and are discussed in terms of the role of nerve fibers containing CGRP in neurogenic inflammation, mechanisms for intensification of CGRP immunoreactivity in affected fibers or neighboring cells, and implications for chronic inflammatory conditions, dental pain, and anesthesia.<\/jats:p>","DOI":"10.1002\/ar.1092220310","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T21:05:13Z","timestamp":1109451913000},"page":"289-300","source":"Crossref","is-referenced-by-count":179,"title":["Inflammation of rat molar pulp and periodontium causes increased calcitonin gene\u2010related peptide and axonal sprouting"],"prefix":"10.1002","volume":"222","author":[{"given":"C. L.","family":"Kimberly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. R.","family":"Byers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(84)90081-2"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/298240a0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/313054a0"},{"key":"e_1_2_1_5_1","volume-title":"Restorative Dentistry","author":"Br\u00e4nnstr\u00f6m M.","year":"1981"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4804633"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7742(08)60677-7"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092050409"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345760550032001"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(82)90012-4"},{"key":"e_1_2_1_11_1","first-page":"3","volume-title":"Neurology and Neurobiology, Vol. 30: Effects of Injury on Trigeminal and Spinal Somatosensory Systems","author":"Byers M. R.","year":"1987"},{"key":"e_1_2_1_12_1","first-page":"127","volume-title":"Degeneration and Regeneration of the Nervous System","author":"Cajal S. Ramon y","year":"1928"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)90239-2"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(74)90401-0"},{"key":"e_1_2_1_15_1","first-page":"15","volume-title":"Sensory Mechanisms of Dentin","author":"Fearnhead R. W.","year":"1963"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(75)90684-8"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1939.0156"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1987.tb02180.x"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(87)90117-3"},{"key":"e_1_2_1_20_1","first-page":"115","volume-title":"Dentine and Pulp: Their Structure and Reactions","author":"Frank R. M.","year":"1968"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1987.tb08108.x"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1523\/JNEUROSCI.04-12-03101.1984","article-title":"Calcitonin gene\u2010related peptide immuno\u2010reactivity in the spinal cord of man and eight other species","volume":"12","author":"Gibson S. J.","year":"1984","journal-title":"J. Neurosci."},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1679\/aohc.45.45"},{"key":"e_1_2_1_24_1","first-page":"1","article-title":"Tachykinins and calcitonin gene\u2010related peptide in relation to peripheral functions of capsaicin\u2010sensitive sensory neurons","volume":"551","author":"Hua X.\u2010Y.","year":"1986","journal-title":"Acta Physiol. Scand., Suppl."},{"key":"e_1_2_1_25_1","doi-asserted-by":"crossref","unstructured":"Khayat B. G. M. R. Byers P. E.Taylor K. B.Mecify andC. L.Kimberly1988Responses of nerve fibers to pulpal inflammation and periapical lesions in rat molars demonstrated by CGRP immunocytochemistry.J. Endodont. in press.","DOI":"10.1016\/S0099-2399(88)80054-2"},{"key":"e_1_2_1_26_1","first-page":"421","article-title":"Demonstration of inflammatory changes to nerve tissue in rat dental pulp using CGRP immunocytochemistry","volume":"13","author":"Kimberly C. L.","year":"1987","journal-title":"J. Endodont."},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/10520294809106242"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90202-9"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(85)90706-X"},{"key":"e_1_2_1_30_1","first-page":"175","article-title":"Substance P as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation. Naunyn\u2010Schmiedeberg's Arch","volume":"310","author":"Lembeck F.","year":"1979","journal-title":"Pharmaco."},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6208609"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/330658a0"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00218053"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)91277-5"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/308653a0"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(87)80043-2"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(87)90034-8"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/002203458506400411"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/002203458506400412"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1987.tb35764.x"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1987.tb35774.x"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/304129a0"},{"key":"e_1_2_1_43_1","first-page":"95","volume-title":"Advances in Inflammation Research","author":"Ross R.","year":"1986"},{"key":"e_1_2_1_44_1","first-page":"1033","article-title":"Neural remodeling following experimental surgery of the rabbit cornea","volume":"24","author":"Rosza A. J.","year":"1983","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.3109\/07367228709144624"},{"key":"e_1_2_1_46_1","doi-asserted-by":"crossref","unstructured":"Taylor P. E. M. R. Byers andP. E.Redd1988Sprouting of CGRP nerve fibers in response to dentin injury in rat molars.Brain Res. in press.","DOI":"10.1016\/0006-8993(88)90270-3"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1977.tb01635.x"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(85)80222-3"},{"key":"e_1_2_1_49_1","first-page":"333","article-title":"Dental pain and the histological condition of the pulp","volume":"20","author":"Tyldesley W. R.","year":"1970","journal-title":"Dent. Pract."},{"key":"e_1_2_1_50_1","first-page":"219","article-title":"Calcitonin gene\u2010related peptide: A sensory transmitter in dental pulps?","volume":"94","author":"Uddman R.","year":"1986","journal-title":"Scand. J. Dent. Res."},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(84)90046-3"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00489551"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(86)90195-3"},{"key":"e_1_2_1_54_1","first-page":"134","article-title":"Immunohistochemical investigations on the nerve fibers of carious teeth","volume":"67","author":"Yamaura Y.","year":"1988","journal-title":"J. Dent. Res."}],"container-title":["The Anatomical Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Far.1092220310","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.1092220310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T02:33:32Z","timestamp":1697855612000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ar.1092220310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,11]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1988,11]]}},"alternative-id":["10.1002\/ar.1092220310"],"URL":"https:\/\/doi.org\/10.1002\/ar.1092220310","archive":["Portico"],"relation":{},"ISSN":["0003-276X","1097-0185"],"issn-type":[{"value":"0003-276X","type":"print"},{"value":"1097-0185","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,11]]}}}