{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T23:28:53Z","timestamp":1772926133951,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,1,26]],"date-time":"2005-01-26T00:00:00Z","timestamp":1106697600000},"content-version":"vor","delay-in-days":5810,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat. Rec."],"published-print":{"date-parts":[[1989,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Morphological studies of secondary palate formation, with special reference to the development of rugae, were carried out on Jcl:ICR mouse embryos. Three rugae were observed on the anterior part of the future oral surface of the vertically developing palatal shelves in 13\u2010day embryos. Rugae increased in number as the development of the palatal shelves proceeded, and five to six prominent rugae were observed in 14\u2010day embryos just prior to shelf elevation. The folding of these five to six rugae progressed in conjunction with the formation of a sharp, valley\u2010like groove at the base of the anterior two\u2010fifths of the vertical palatal shelves. As palatal shelves elevated, the groove disappeared gradually, and, accordingly, the folding of rugae loosened. In the groove region, the superficial epithelial cells were roundish, while the basal ones were elongated. Such characteristic features were no longer observed when the disappearance of the groove was completed. Eight rugae were observed on the future hard palate of 14\u2010day embryos with already completed palatal fusion. An additional ruga was frequently found in 15\u2010day embryos, and the pattern then was almost the same as that of an adult. Epithelial thickening and condensation at the rugae region, as well as mesenchymal condensation under the epithelium of the rugae, were confirmed in embryos both before and after elevation of the palatal shelves. There is a possibility that structural characteristics observed in the epithelial and mesenchymal cells of the rugae and groove regions may be related to palatal shelf elevation.<\/jats:p>","DOI":"10.1002\/ar.1092230309","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T22:28:30Z","timestamp":1109456910000},"page":"299-310","source":"Crossref","is-referenced-by-count":29,"title":["Morphogenesis of the secondary palate in mouse embryos with special reference to the development of rugae"],"prefix":"10.1002","volume":"223","author":[{"given":"Michiko Kamimura","family":"Sakamoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosyo","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Handa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahide","family":"Kihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Tanimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,1,26]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420200210"},{"key":"e_1_2_1_3_1","first-page":"533","article-title":"Diff\u00e9renciation tissulaire \u00e9pith\u00e9liale et m\u00e9senchymateuse au cours de la formation du palais secondaire chez l'embryon de rat","volume":"28","author":"Benoit R.","year":"1974","journal-title":"Actual. Odontostomatol. (Paris)"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420220213"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(84)90186-6"},{"key":"e_1_2_1_6_1","first-page":"265","article-title":"The influence of the epithelium on palate shelf reorientation","volume":"88","author":"Bulleit R. F.","year":"1985","journal-title":"J. Embryol. Exp. Morphol."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091510202"},{"key":"e_1_2_1_8_1","first-page":"555","article-title":"Palatal shelf elevation in the Wistar rat fetus","volume":"125","author":"Ferguson M. W. J.","year":"1978","journal-title":"J. Anat."},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1179\/bjo.8.3.115"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.158.3808.1603"},{"key":"e_1_2_1_11_1","first-page":"225","article-title":"Developmental aspects of secondary palate formation","volume":"36","author":"Greene R. M.","year":"1976","journal-title":"J. Embryol. Exp. Morphol."},{"key":"e_1_2_1_12_1","first-page":"137A","article-title":"A formaldehyde\u2010glutaraldehyde fixative of high osmolatily for use in electron microscopy","volume":"27","author":"Karnovsky M. J.","year":"1965","journal-title":"J. Cell. Biol."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-4520.1984.tb00940.x"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.9.2.409"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000145287"},{"key":"e_1_2_1_16_1","first-page":"251","article-title":"Epithelial proliferation and development of rugae in relation to palatal shelf evaluation in the mouse","volume":"138","author":"Luke D. A.","year":"1984","journal-title":"J. Anat."},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091980210"},{"key":"e_1_2_1_18_1","first-page":"169","article-title":"Prenatal development of rugae palatinae in mice: Scanning electron microscopic and histological studies","volume":"7","author":"Peterkov\u00e1 R.","year":"1987","journal-title":"J. Craniofac. Genet. Dev. Biol."},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-648350-5.50010-3"},{"key":"e_1_2_1_20_1","first-page":"69","volume-title":"Advances in the Study of Birth Defects","author":"Shah R. M.","year":"1979"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091800111"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091760311"}],"container-title":["The Anatomical Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Far.1092230309","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.1092230309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T08:14:26Z","timestamp":1697962466000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ar.1092230309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,3]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1989,3]]}},"alternative-id":["10.1002\/ar.1092230309"],"URL":"https:\/\/doi.org\/10.1002\/ar.1092230309","archive":["Portico"],"relation":{},"ISSN":["0003-276X","1097-0185"],"issn-type":[{"value":"0003-276X","type":"print"},{"value":"1097-0185","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,3]]}}}