{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T13:40:38Z","timestamp":1698068438941},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,2,22]],"date-time":"2005-02-22T00:00:00Z","timestamp":1109030400000},"content-version":"vor","delay-in-days":5806,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat. Rec."],"published-print":{"date-parts":[[1989,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It has been well established that heterologous antibodies against certain tissue components may cause congenital abnormalities when injected into pregnant rats during the critical period of organogenesis. A glycoprotein antigen (gp340) of rat renal proximal tubules was isolated (C.C.K. Leung: (<jats:italic>J. Exp. Med., 156:<\/jats:italic>372\u2013384, 1982); antibodies against gp340 were teratogenic.<\/jats:p><jats:p>Indirect colloidal gold immunocytochemical method was utilized to study the ultrastructural localization of gp340. For comparative studies, both preembedding and postembedding immunostaining procedures were used. The results indicate that gp340 is a resident of coated pits and possibly also of coated vesicles of the rat renal proximal tubules and visceral yolk\u2010sac (VYS) endodermal cells. It appears that gp340 may also be associated with the microvilli and some as\u2010yet\u2010unidentified cytoplasmic structures of the same tissues. However, gp340 is absent on the epithelium of the small intestine.<\/jats:p><jats:p>It is hypothesized that the teratogenic antibodies may interact with gp340 on the coated pits and interfere with receptor\u2010mediated endocytosis, causing yolk\u2010sac placenta dysfunction which in turn causes abnormal embryonic development.<\/jats:p>","DOI":"10.1002\/ar.1092230403","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T22:29:55Z","timestamp":1109456995000},"page":"363-367","source":"Crossref","is-referenced-by-count":4,"title":["Teratogenic antibodies are directed against a coated\u2010pit glycoprotein"],"prefix":"10.1002","volume":"223","author":[{"given":"Christopher C. K.","family":"Leung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boonlert","family":"Cheewatrakoolpong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cai\u2010Lou","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,22]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401760106"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/35.9.3302022"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.4049\/jimmunol.105.5.1175","article-title":"Production of congenital malformations using tissue antisera. VIII. Effectiveness of reduced, alkylated and digested antikidney antibodies","volume":"105","author":"Bragonier J. R.","year":"1970","journal-title":"J. Immunol."},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-106-26390"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420040302"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.1982.tb00362.x"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","unstructured":"Cheewatrakoolpong B. andC. C. K.Leung1988Effects of teratogenic antibodies on cultured visceral yolk\u2010sac endodermal cells: Cytotoxicity and morphological studies.J. Exp. Zool. in press.","DOI":"10.1002\/jez.1402480310"},{"key":"e_1_2_1_9_1","first-page":"939","article-title":"Action teratogene d'heteroanticorps tissulaires. I. Production de malformations chez le rat par action d'un serum antirein","volume":"157","author":"David G.","year":"1963","journal-title":"C.R. Seances Soc. Biol. Fil."},{"key":"e_1_2_1_10_1","first-page":"63","article-title":"The effect of teratogenic antiserum on yolk\u2010sac function in rats embryos cultured in vitro","volume":"71","author":"Freeman S. J.","year":"1982","journal-title":"J. Embryol. Exp. Morphol."},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","unstructured":"Freeman S. J. R. Marlow andC. C. K.Leung1989Anti\u2010kidney antibody teratogenesis: Evidence for a direct action on the rat conceptus by a mechanism involving the yolk sac.Teratology submitted.","DOI":"10.1016\/0378-4274(89)90076-3"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420030206"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1982.62.1.91"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.98.4.1505"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.156.2.372"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198305000-00002"},{"key":"e_1_2_1_17_1","first-page":"49","article-title":"Ultrastructural pathologic changes of rat extraembryonic visceral endodermal cells exposed to teratogenic antibodies in vivo","volume":"3","author":"Leung C. C. K.","year":"1988","journal-title":"Histol. Histopathol."},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(85)90325-2"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"885","DOI":"10.4049\/jimmunol.113.3.885","article-title":"Evidence that different antibodies are involved in the production of immunologically induced teratogenesis and nephritis","volume":"113","author":"Leung C. C. K.","year":"1974","journal-title":"J. Immunol."},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/22.12.1077"},{"key":"e_1_2_1_21_1","first-page":"97","article-title":"Pathogenic action of nephrocytotoxic serum on embryonic development of albino rats","volume":"63","author":"Mikhailov V. M.","year":"1976","journal-title":"Biul. Eksp. Biol. Med."},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00514337"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.1.213"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)41346-X"},{"key":"e_1_2_1_25_1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0002-9378(72)90068-3","article-title":"Inhibitory effects of nephrotoxic antisera on the growth of rat fetuses","volume":"114","author":"Vaillancourt P.","year":"1972","journal-title":"Am. J. Obstet. Gyncol."}],"container-title":["The Anatomical Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Far.1092230403","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.1092230403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T05:09:19Z","timestamp":1697951359000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ar.1092230403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,4]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1989,4]]}},"alternative-id":["10.1002\/ar.1092230403"],"URL":"https:\/\/doi.org\/10.1002\/ar.1092230403","archive":["Portico"],"relation":{},"ISSN":["0003-276X","1097-0185"],"issn-type":[{"value":"0003-276X","type":"print"},{"value":"1097-0185","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,4]]}}}