{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T12:00:54Z","timestamp":1698235254638},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,2,8]],"date-time":"2005-02-08T00:00:00Z","timestamp":1107820800000},"content-version":"vor","delay-in-days":5517,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat. Rec."],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The binding of a panel of blood group\u2010reactive lectins to frozen sections of human kidney was studied with a special emphasis on reactivity with endothelia and basement membranes. The blood group A\u2010reactive lectins, all specific for \u03b1\u2010D\u2010<jats:italic>N<\/jats:italic>\u2010acetylgalactosamine (GalNAc), <jats:italic>Helix aspersa<\/jats:italic> (HAA), <jats:italic>Helix pomatia<\/jats:italic> (HPA), and <jats:italic>Griffonia simplicifolia<\/jats:italic> I\u2010A<jats:sub>4<\/jats:sub> (GSA\u2010I\u2010A<jats:sub>4<\/jats:sub>) agglutinins bound to the endothelium in specimens with blood groups A and AB. In other samples, these lectins reacted predominantly with tubular basement membranes, as well as with certain tubules. Both <jats:italic>Dolichos biflorus<\/jats:italic> (DBA) and <jats:italic>Vicia villosa<\/jats:italic> agglutinins (VVA), reported to react with blood group A<jats:sub>1<\/jats:sub> substance, failed to reveal endothelia in most specimens, but bound differently to tubules in all blood groups. The blood group B\u2010reactive lectins, specific for \u03b1\u2010D\u2010galactose (\u03b1\u2010Gal) or GalNAc, respectively, GSA\u2010I\u2010B<jats:sub>4<\/jats:sub> and <jats:italic>Sophora japonica<\/jats:italic> agglutinin (SJA), bound to the endothelia in specimens from blood group B or AB and in other specimens bound only to certain tubules. Among the blood group O\u2010reactive lectins, specific for \u03b1\u2010L\u2010fucose (Fuc), <jats:italic>Ulex europaeus<\/jats:italic> I agglutinin (UEA\u2010I) conjugates, but not other lectins with a similar nominal specificity, bound strongly to endothelia in specimens with blood group O. The UEA\u2010I conjugates bound distinctly more faintly to endothelia in specimens of other blood groups. The present results indicate that lectins, binding to defined blood group determinants, react with endothelia in specimens of the respective blood group status. Furthermore, they suggest that basement membranes and some tubules in the human kidney show a distinct heterogeneity in their expression of saccharide residues, related to their blood group status.<\/jats:p>","DOI":"10.1002\/ar.1092260103","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T21:00:23Z","timestamp":1109451623000},"page":"10-17","source":"Crossref","is-referenced-by-count":21,"title":["Binding of the blood group\u2010reactive lectins to human adult kidney specimens"],"prefix":"10.1002","volume":"226","author":[{"given":"Liisa","family":"Laitinen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harri","family":"Juusela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismo","family":"Virtanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,8]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00489554"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1980.94"},{"key":"e_1_2_1_4_1","first-page":"5","article-title":"Lectin cytochemistry and histochemistry","volume":"57","author":"Damjanov I.","year":"1987","journal-title":"Lab. 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