{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:07:01Z","timestamp":1790233621432,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,2,8]],"date-time":"2005-02-08T00:00:00Z","timestamp":1107820800000},"content-version":"vor","delay-in-days":5244,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat. Rec."],"published-print":{"date-parts":[[1990,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An injection of estradiol valerate (EV) in the rat produces an anovulatory polycystic ovarian (PCO) condition. Chronic estrogen exposure, produced by subcutaneously implanted, estradiol (E<jats:sub>2<\/jats:sub>)\u2010containing chronic release capsules, results in acyclicity and in hypothalamic changes similar to those seen in the EV\u2010injected rat. We, therefore, examined the ovarian histology and plasma gonadotropin patterns in the E<jats:sub>2<\/jats:sub>\u2010implanted rat and found that this model exhibits a poiycystic ovarian condition and a plasma gonadotropin pattern very different from those in the EV\u2010treated model. The plasma patterns of LH and FSH are bimodal consisting of small frequent pulses as well as less frequent large episodes of long duration. The ovaries contain multiple small cysts, characterized by an extensively hypertrophied theca interna, and vast chords of hypertrophied secondary interstitial cells. In contrast, cystic follicles in EV\u2010treated rats are fewer in number, but much larger than those in the E<jats:sub>2<\/jats:sub>\u2010implanted animals. The cystic theca and the secondary interstitial cell clusters are also far less extensive in the EV\u2010induced poiycystic ovary. These and other differences between the two types of PCO indicate that they are produced by fundamentally different morphogenic mechanisms. The cystic ovary produced by the E<jats:sub>2<\/jats:sub> implants is similar in appearance to that seen in the human Stein\u2010Leventhal condition, and thus provides a new model for the study of cystic ovarian disease.<\/jats:p>","DOI":"10.1002\/ar.1092280205","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T20:49:51Z","timestamp":1109450991000},"page":"137-144","source":"Crossref","is-referenced-by-count":17,"title":["Induction of stein\u2010leventhal\u2010like polycystic ovaries (PCO) in the rat: A new model for cystic ovarian disease"],"prefix":"10.1002","volume":"228","author":[{"given":"Gerald F.","family":"McCarthy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Brawer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,8]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92552-8"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.293.6543.355"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00233915"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod35.3.647"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90544-9"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-103-2-501"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-107-1-274"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-112-1-194"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod38.3.562"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1139\/y89-140"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","unstructured":"ConveryM. G. F.McCarthy andJ. R.Brawer1990Remission of the polycystic ovarian condition (PCO) in the rat following hemiovariectomy. Anat. Rec. (in press).","DOI":"10.1002\/ar.1092260309"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092250206"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-110-5-1618"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-6-3-371"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod32.3.530"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-116-4-1485"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod24.4.771"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1140033"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod29.1.239"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-64-4-755"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","unstructured":"McCarthyG. F. J. R.Brawer andR.Farookhi1990Plasma gonadotropin patterns characterizing the development of polycystic ovaries (PCO) in the estradiol valerate (EV)\u2010treated rat. Can. J. Physiol. Pharmacol. (in press).","DOI":"10.1139\/y90-003"},{"issue":"1","key":"e_1_2_1_23_1","first-page":"172","article-title":"Polycystic ovaries (PCO) occur in response to a specific pulsatile pattern of luteinizing hormone (LH)","volume":"36","author":"McCarthy G. F.","year":"1987","journal-title":"Biol. 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