{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:02:42Z","timestamp":1760644962253},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,1,26]],"date-time":"2005-01-26T00:00:00Z","timestamp":1106697600000},"content-version":"vor","delay-in-days":4714,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat. Rec."],"published-print":{"date-parts":[[1992,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Injection of 5\u03b1\u2010dihydrotestosterone (DHT) into castrated adult female mice stimulated the proliferation of a small proportion of the convoluted tubular cells in the submandibular glands. We investigated the effects of DHT and thyroxine (T<jats:sub>4<\/jats:sub>) on the maintenance of these proliferated convoluted tubular cells. For this, castrated adult female mice that had been treated daily with DHT for 3 days and then once with [<jats:sup>3<\/jats:sup>H]thymidine, received a first series of daily injections of DHT for various periods or T<jats:sub>4<\/jats:sub> for 10 days, and then a second series of injections of treatment with DHT or T<jats:sub>4<\/jats:sub>, or no further treatment. The second series of treatments with DHT or T<jats:sub>4<\/jats:sub> maintained the percentages of <jats:sup>3<\/jats:sup>H\u2010labeled convoluted tubular cells at similar or slightly lower levels than those at the end of the first series of treatments. In mice that did not receive the second series of treatments, the percentages of <jats:sup>3<\/jats:sup>H\u2010labeled convoluted tubular cells decreased markedly, becoming significantly lower than those at the end of the second series of treatment with DHT or T<jats:sub>4<\/jats:sub>. We also examined the effect of DHT on the proliferation of convoluted tubular cells of castrated adult female mice that had received 10 daily injections of DHT and then no treatment for 28 days. In these mice, the cells did not proliferate markedly on stimulation with DHT. These results suggest that androgen and thyroid hormone maintain convoluted tubular cells that have proliferated in response to androgen, and that the convoluted tubular cells may become unresponsive to androgen in terms of proliferation after their exposure to androgen.<\/jats:p>","DOI":"10.1002\/ar.1092320314","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T20:08:03Z","timestamp":1109448483000},"page":"453-457","source":"Crossref","is-referenced-by-count":5,"title":["Maintenance by androgen and thyroid hormone of androgen\u2010induced convoluted tubular cells in mouse submandibular glands"],"prefix":"10.1002","volume":"232","author":[{"given":"Mariko","family":"Oda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiko","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Terada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuko","family":"Nishizawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daishiro","family":"Takatsuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiko","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keishi","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,1,26]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/28.8.7003006"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0083-6729(08)60951-6"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj0620315"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(08)60101-1"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.0910335"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/42.5.491"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-109-3-924"},{"key":"e_1_2_1_9_1","first-page":"87","article-title":"Deletion of cells by apoptosis during castration induced involution of rat prostate","volume":"13","author":"Kerr J. 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