{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:34:17Z","timestamp":1760204057207},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,1,26]],"date-time":"2005-01-26T00:00:00Z","timestamp":1106697600000},"content-version":"vor","delay-in-days":4530,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat. Rec."],"published-print":{"date-parts":[[1992,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A low dose of Cyproterone acetate (CPA; 1 mg\/kg body weight\/day for 70 days) was administered to adult male rhesus monkeys to assess its effects on testicular and epididymal structure and function in a nonhuman primate species. CPA caused extensive degenerative changes in morphology of seminiferous, efferent duct, and epididymal epithelia, including decrease in diameter of seminiferous and epididymal tubules and their lumen, height of epididymal epithelium, and an increase in intertubular connective tissue. The protein profile of spermatozoa showed alterations during their epididymal transit in control and CPA\u2010treated monkeys. In CPA\u2010treated animals, 19 polypeptides were acquired and nine were eliminated during epididymal transit in contrast to acquisition of 12 and loss of 14 polypeptides in control animals. Treatment with CPA also resulted in the appearance of 14 new polypeptides in epididymal cytosol and luminal fluid, probably of lysosomal origin. The protein pattern of caput and cauda epididymal tubule cytosol, maintained in organ culture and exposed to 100 \u03bcM CPA for 3 days, showed absence of eight polypeptides.<\/jats:p><jats:p>These results indicate that even at the low dose used in this study, CPA has caused spermatogenic arrest, degenerative changes in the epididymal structure, and alterations in epididymal and sperm protein profile. Suppression of serum testosterone levels indicates the need for androgen supplementation if CPA is to be used for male contraception. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ar.1092340108","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T19:56:00Z","timestamp":1109447760000},"page":"62-72","source":"Crossref","is-referenced-by-count":16,"title":["Effect of cyproterone acetate on structure and function of rhesus monkey reproductive organs"],"prefix":"10.1002","volume":"234","author":[{"given":"Jagdeep","family":"Kaur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. R.","family":"Ramakrishnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Rajalakshmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,1,26]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod19.5.1063"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/01485018608986924"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(69)90227-7"},{"key":"e_1_2_1_5_1","volume-title":"Laboratory Manual for the Examination of Human Semen and Semen\u2010cervical Mucus Interaction","author":"Belsey M. A.","year":"1980"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1969.tb16007.x"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/030006057400200211"},{"key":"e_1_2_1_8_1","first-page":"865","article-title":"Histochemical localization of dehydrogenases in different regions of the epididymis of the adult rhesus monkey (Macaca mulatta)","volume":"15","author":"Dinakar N.","year":"1977","journal-title":"Ind. J. Exp. Biol."},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-93-2-391"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001740305"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajp.1350040107"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1111126"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(91)90148-9"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(76)90081-0"},{"key":"e_1_2_1_15_1","first-page":"345","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"43","author":"Laemlli U. K.","year":"1970","journal-title":"Nature (Lond.)"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-112-28242"},{"key":"e_1_2_1_17_1","first-page":"197","article-title":"Preliminary studies on the effects of cyproterone acetate on sexual activity and testicular function in adult male rhesus monkeys (Macaca mulatta)","volume":"10","author":"Michael R. P.","year":"1972","journal-title":"Adv. Biol. Sci."},{"key":"e_1_2_1_18_1","first-page":"14","article-title":"Effect of cyproterone acetate (CPA) on pituitary gonadotrophin release and on androgen secretion before and after LH\u2010RH double stimulation of testis in men","volume":"2","author":"Moltz L.","year":"1978","journal-title":"Int. J. Androl."},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0320365"},{"key":"e_1_2_1_20_1","first-page":"129","article-title":"New antiandrogens and their mode of action","volume":"24","author":"Neumann F.","year":"1976","journal-title":"J. Reprod. Fertil."},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1094040"},{"key":"e_1_2_1_22_1","unstructured":"Prakash A.1980Light and electron microscopic studies on the excurrent ducts of the male reproductive system in the adult rhesus monkey. Ph. D. thesis Delhi University."},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02706331"},{"key":"e_1_2_1_24_1","first-page":"153","volume-title":"Int. Review Physiol. Reproductive Physiology II","author":"Prasad M. R. N.","year":"1977"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.1974.tb01622.x"},{"key":"e_1_2_1_26_1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0015-0282(16)40933-7","article-title":"Action of cyproterone acetate on the accessory organs of reproduction in pre\u2010pubertal and sexually mature rats","volume":"2","author":"Rajalakshmi M.","year":"1975","journal-title":"Fertil. Steril."},{"key":"e_1_2_1_27_1","first-page":"71","article-title":"Physiology of the epididymis and induction of functional sterility in the male","volume":"24","author":"Rajalakshmi M.","year":"1976","journal-title":"J. Reprod. Fertil. Suppl."},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0039-128X(83)90024-7"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(89)90048-6"},{"key":"e_1_2_1_30_1","first-page":"455","article-title":"Effects of drugs on the epididymis","volume":"41","author":"Ratnasooriya W. D.","year":"1982","journal-title":"J. Sci. Ind. Res."},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001490407"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(79)90282-6"},{"key":"e_1_2_1_33_1","first-page":"595","article-title":"Influence of an antiandrogen (cyproterone) on the gonadotrophic function of the pituitary gland, on the gonad and on metabolism in normal men","volume":"63","author":"Rausch\u2010Stroomann J. G.","year":"1970","journal-title":"Acta Endocrinol. Kbh."},{"key":"e_1_2_1_34_1","first-page":"999","volume-title":"The Physiology of Reproduction","author":"Robaire B.","year":"1988"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(79)90099-2"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(76)80055-8"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02900504"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(66)90050-9"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod32.2.399"}],"container-title":["The Anatomical Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Far.1092340108","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.1092340108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T18:06:55Z","timestamp":1698170815000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ar.1092340108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,9]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1992,9]]}},"alternative-id":["10.1002\/ar.1092340108"],"URL":"https:\/\/doi.org\/10.1002\/ar.1092340108","archive":["Portico"],"relation":{},"ISSN":["0003-276X","1097-0185"],"issn-type":[{"value":"0003-276X","type":"print"},{"value":"1097-0185","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,9]]}}}