{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T08:33:43Z","timestamp":1700296423025},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,1,26]],"date-time":"2005-01-26T00:00:00Z","timestamp":1106697600000},"content-version":"vor","delay-in-days":4196,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat. Rec."],"published-print":{"date-parts":[[1993,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of pretreatment with androgen or thyroid hormone on androgen\u2010induced proliferation of granular convoluted tubular cells (GCT cells) in the submandibular glands of ovariectomized female BALB\/c or C57BL\/6 mice were investigated. The proliferation of GCT cells was estimated by their labeling index. Daily injections of 5\u03b1\u2010dihydrotestosterone (DHT) (100 \u03bcg\/mouse\/day) caused a transient increase in the labeling index of GCT cells of ovariectomized 60\u2010day\u2010old BALB\/c mice during the first four injections, but injections of thyroxine (T<jats:sub>4<\/jats:sub>) (15 \u03bcg\/mouse\/day) did not. On the other hand, both DHT and T<jats:sub>4<\/jats:sub> increased the esteroprotease activity, a marker of the differentiation of GCT cells, time dependently. Injections of DHT into ovariectomized 102\u2010day\u2010old BALB\/c mice also caused a transient increase in the labeling index of GCT cells. However, pretreatment of ovariectomized 60\u2010day\u2010old BALB\/c mice with DHT for 4 or 14 days completely abolished the DHT\u2010induced increase in the labeling index of 102\u2010day\u2010old mice, and pretreatment with T<jats:sub>4<\/jats:sub> for 14 days reduced this increase. Pretreatment with DHT or T<jats:sub>4<\/jats:sub> for 14 days did not affect the DHT\u2010induced increase in esteroprotease activity. Pretreatment of ovariectomized 60\u2010day\u2010old C57BL\/6 mice with DHT for 14 days also completely abolished the DHT\u2010induced increase in the labeling index of GCT cells at the age of 102 days, but pretreatment with T<jats:sub>4<\/jats:sub> for 14 days did not affect the increase. These results suggest that the proliferation of mouse GCT cells induced by androgen results in a complete abolition of their proliferative response to androgen, and that the effect of thyroid hormone on the proliferative response of GCT cells to androgen may differ in different strains of mice. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ar.1092360412","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T19:43:21Z","timestamp":1109447001000},"page":"679-684","source":"Crossref","is-referenced-by-count":3,"title":["Effects of pretreatment with androgen or thyrold hormone on androgen\u2010induced proliferation of granular convoluted tubular cells in mouse submandibular glands"],"prefix":"10.1002","volume":"236","author":[{"given":"Jun","family":"Fang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiko","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daishiro","family":"Takatsuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motomu","family":"Tsuji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Terada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,1,26]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(80)90183-4"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/28.8.7003006"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-197102000-00009"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0083-6729(08)60951-6"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj0620315"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(08)60101-1"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/25.9.333017"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/33.12.3877752"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/42.5.491"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-109-3-924"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092000407"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1093\/oxfordjournals.jbchem.a133379","article-title":"Induction of various androgen dependent esteroproteases (trypsin\u2010like and chymotrypsin\u2010like enzymes) by triiodo\u2010L\u2010thyroxine in the submandibular glands of female mice and mice with testicular feminization","volume":"89","author":"Hosoi K.","year":"1981","journal-title":"J. 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