{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T11:08:49Z","timestamp":1780657729307,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,1,27]],"date-time":"2005-01-27T00:00:00Z","timestamp":1106784000000},"content-version":"vor","delay-in-days":4136,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat. Rec."],"published-print":{"date-parts":[[1993,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The ultrastructural characteristics of the glomus cells in the rat carotid body exposed to extremely long\u2010term hypoxia (10\u201312 weeks) were investigated. The glomus cells could be classified into four distinct types according to the shape of dense\u2010cored vesicles in the glomus cell cytoplasm: (1) small vesicle cells (SVCs, 50 nm in mean diameter), (2) large vesicle cells (LVCs, 80 nm in mean diameter), (3) dilated eccentric vesicle cells (EVCs, 400\u2013800 nm in diameter), and (4) mixed vesicle cells (MVCs, large and eccentric vesicles). Many clusters of glomus cells were found to contain all four categories of cell types. The appearance of EVCs was a unique and common characteristic of glomus cells in this long\u2010term hypoxia model. We also noted other ultrastructural features with chronic hypoxia which are characteristic of the amphibian carotid labyrinth glomus cells: (1) incomplete covering of glomus cells with the supporting cell missing over a wide area, (2) long thin cytoplasmic projections in the intervascular stroma, and (3) intimate apposition of the glomus cells and pericytes (g\u2010p connection), endothelial cells (g\u2010e connection), plasma cells, and fibrocytes. Because arterial PO<jats:sub>2<\/jats:sub> is generally low in amphibia, these may be general features of hypoxic adaptation and facilitate both uptake of oxygen from blood and release of catecholamine into the blood. The g\u2010p and g\u2010e connections may take part in the regulation of the microcirculation in the enlarged carotid body. \u00a9 1993 Wiley\u2010Liss Inc.<\/jats:p>","DOI":"10.1002\/ar.1092370209","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T19:46:26Z","timestamp":1109447186000},"page":"220-227","source":"Crossref","is-referenced-by-count":25,"title":["Ultrastructure of the glomus cells in the carotid body of chronically hypoxic rats: With special reference to the similarity of amphibian glomus cells"],"prefix":"10.1002","volume":"237","author":[{"given":"Tatsumi","family":"Kusakabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank L.","family":"Powell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark H.","family":"Ellisman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,1,27]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.74.4.1635"},{"key":"e_1_2_1_3_1","first-page":"202","volume-title":"The Comparative Morphology of the Carotid Body and Carotid Sinus","author":"Adams W. 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