{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:12:50Z","timestamp":1771632770746,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,1,26]],"date-time":"2005-01-26T00:00:00Z","timestamp":1106697600000},"content-version":"vor","delay-in-days":3831,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat. Rec."],"published-print":{"date-parts":[[1994,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background<\/jats:italic>: A substantial part of the endocrine pancreas has been previously described as being located either close to the excretory ducts as small clusters of endocrine cells and as Islets of Langerhans, or associated with the ducts as single endocrine cells scattered through the ductal epithelium.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>: Four Wistar white adult rats were sacrificed and perfused via the thoracic aorta with 2.5% glutaraldehyde. After the usual treatment for the transmission electron microscopy, pieces of pancreas were sectioned consecutively for light microscopy. Consecutive ultrathin sections were performed in the most interesting cases.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: The observations previously reported were confirmed. In addition, a new endocrine arrangement was detected and described as buds of endocrine cells (mainly B\u2010cells) protruding from the ductal epithelium into the surrounding tissue.<\/jats:p><jats:p><jats:italic>Conclusions<\/jats:italic>: The authors propose to explain the endocrine buds as components of the gastro\u2010entero\u2010pancreatic system or as a stage of an endocrine pancreatic \u201cneo\u2010histogenesis\u201d occurring in the adult rat pancreas. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ar.1092390404","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T19:35:21Z","timestamp":1109446521000},"page":"371-378","source":"Crossref","is-referenced-by-count":16,"title":["Endocrine tissue associated with the pancreatic ductal system: A light and electron microscopic study of the adult rat pancreas with special reference to a new endocrine arrangement"],"prefix":"10.1002","volume":"239","author":[{"given":"Eugenio","family":"Bertelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari'","family":"Regoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaldo","family":"Bastianini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,1,26]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00220651"},{"key":"e_1_2_1_3_1","first-page":"G599","article-title":"Capillary orientation of rat pancreatic D cell processes: Evidence for endocrine release of somatostatin","volume":"249","author":"Aponte G.","year":"1985","journal-title":"Am. J. Physiol."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.390711"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02890112"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-198707000-00005"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00548522"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02889153"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00716988"},{"key":"e_1_2_1_10_1","first-page":"403","volume-title":"The Pancreas Biology, Pathobiology, and Disease","author":"Chey W. Y.","year":"1993"},{"key":"e_1_2_1_11_1","first-page":"769","volume-title":"The Pancreas Biology, Pathobiology, and Disease","author":"Creutzfeldt W.","year":"1993"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02892846"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00548648"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.27.1.S251"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-198807000-00004"},{"key":"e_1_2_1_16_1","first-page":"21","volume-title":"The Pancreas Biology, Pathobiology, and Disease","author":"Githens S.","year":"1993"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00492250"},{"key":"e_1_2_1_18_1","first-page":"69","article-title":"Phases in the early development of the human islet organ","volume":"166","author":"Hahn von Dorsche H.","year":"1988","journal-title":"Anat. Anz."},{"key":"e_1_2_1_19_1","first-page":"239","article-title":"Determination of mitoses in the human fetal pancreas: A contribution on islets cell development","volume":"167","author":"Hahn von Dorsche H.","year":"1988","journal-title":"Anat. Anz."},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00698661"},{"key":"e_1_2_1_21_1","first-page":"297","article-title":"A light and electron microscopic study on the pancreatic ductal system","volume":"33","author":"Kodama T.","year":"1983","journal-title":"Acta Pathol. Jpn."},{"key":"e_1_2_1_22_1","unstructured":"Langerhans P.1869Beitr\u00e4ge zur mikroskopischen Anatomie der Bauchspeicheldr\u00fcse. Inaugural Dissertation Berlin."},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00432397"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00221800"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00422088"},{"key":"e_1_2_1_26_1","first-page":"G268","article-title":"An important role of endogenous insulin on exocrine pancreatic secretion in rats","volume":"258","author":"Lee K. Y.","year":"1990","journal-title":"Am. J. Physiol."},{"key":"e_1_2_1_27_1","first-page":"33","article-title":"Close association of centroacinar\/ductular and insular cells in the rat pancreas","volume":"1","author":"Leeson T.","year":"1986","journal-title":"Histol. Histopathol."},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.21.2.S511"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-198908000-00013"},{"key":"e_1_2_1_30_1","first-page":"569","volume-title":"Basic and Clinical Endocrinology","author":"Mulvihill S. J.","year":"1991"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000145300"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1993.sp019602"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092320209"},{"key":"e_1_2_1_34_1","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0016-5085(77)80291-6","article-title":"Immunohistochemical localization of human pancreatic polypeptide (HPP) in the human endocrine pancreas","volume":"72","author":"Pelletier G.","year":"1977","journal-title":"Gastroenterology"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.17.1.208"},{"key":"e_1_2_1_36_1","first-page":"75","article-title":"Induction of endocrine cell differentiation: A new approach to management of diabetes","volume":"114","author":"Rosenberg L.","year":"1989","journal-title":"J. Lab. Clin. Med."},{"key":"e_1_2_1_37_1","first-page":"111","article-title":"An islet of Langerhans located within the epithelium of a human pancreatic duct","volume":"1","author":"Swartz F. J.","year":"1986","journal-title":"Histol. Histopathol."},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1679\/aohc.51.315"}],"container-title":["The Anatomical Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Far.1092390404","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.1092390404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T16:47:18Z","timestamp":1698166038000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ar.1092390404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,8]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,8]]}},"alternative-id":["10.1002\/ar.1092390404"],"URL":"https:\/\/doi.org\/10.1002\/ar.1092390404","archive":["Portico"],"relation":{},"ISSN":["0003-276X","1097-0185"],"issn-type":[{"value":"0003-276X","type":"print"},{"value":"1097-0185","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,8]]}}}