{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:28:17Z","timestamp":1761596897166},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,1,26]],"date-time":"2005-01-26T00:00:00Z","timestamp":1106697600000},"content-version":"vor","delay-in-days":3739,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat. Rec."],"published-print":{"date-parts":[[1994,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background<\/jats:italic>: Astrocytes within the hypothalamic arcuate nucleus contain Gomori\u2010positive inclusions that exhibit a nonenzymatic peroxidase activity. The source and composition of these Gomori\u2010positive inclusions are currently unknown. Recent evidence, derived from cultured astrocytes, suggests that Gomori\u2010positive inclusions may consist of autophagocytized accumulations of altered mitochondria and that the peroxidase activity is generated by iron or other metals which accumulate in these mitochondria.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>: The present study applies electron microscopy, energy dispersive X\u2010ray microanalysis, and immunocytochemistry in conjunction with confocal microscopy to determine the structure and composition of Gomori\u2010positive inclusions in vivo.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: The results indicate that Gomori\u2010positive inclusions are heterogeneous structures often associated with microtubules and that they contain conspicuous mitochondrial components. Gomori\u2010positive inclusions exhibit X\u2010ray emission peaks for copper and, less often, chromium, either of which could account for the peroxidase activity.<\/jats:p><jats:p><jats:italic>Conclusions<\/jats:italic>: These results support the hypothesis that Gomori\u2010positive inclusions are autophagosomes in which mitochondria are prominent. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ar.1092400313","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T19:02:27Z","timestamp":1109444547000},"page":"407-415","source":"Crossref","is-referenced-by-count":30,"title":["Composition of Gomori\u2010positive inclusions in astrocytes of the hypothalamic arcuate nucleus"],"prefix":"10.1002","volume":"240","author":[{"given":"James R.","family":"Brawer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Stein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorne","family":"Small","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soriba","family":"Ciss\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyman M.","family":"Schipper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,1,26]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(82)90050-6"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod49.4.647"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)91516-4"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-107-1-274"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-112-1-194"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001440105"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(88)90059-7"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0047-6374(76)90018-X"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.132.1.86"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000144642"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00234404"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/8755-9668(86)90017-7"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(84)90046-0"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.8564185"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/40.1.1729356"},{"key":"e_1_2_1_17_1","first-page":"151","volume-title":"Catechol Estrogens","author":"MacLusky N. 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