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Rec."],"published-print":{"date-parts":[[1995,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background<\/jats:italic>: In a previous study at the LM level we have found an increase in the density of innervation of axillary lymph nodes of the rat 4 months after antigenic stimulation.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>: To reduce the variability of the results, animals reared under sterile conditions, and stimulated by subcutaneous application of bovine albumin, were used. The control group of animals was compared with three experimental groups surviving the application of antigen for varying periods, so that the ascending phase, the peak, and the descending phase of production of antibodies were represented. The present publication presents the results of the same experiment, but with an ultrastructural analysis of axonal profiles and their spatial relationship to the cells of the lymph node.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: The present study indicates that, at the ultrastructural level, significant changes occur also during the early phase of the immune response, 10 days after application of antigen. In the short\u2010term response these changes take the form of an increase in the proportion of unensheathed axonal profiles (open areas) that contain vesicles, a more frequent association of open areas containing vesicles with cells, and an increase in the size of the open areas. In the long\u2010term reaction there is a general increase in the number of all open areas, but a reduction in the proportion that contains vesicles.<\/jats:p><jats:p><jats:italic>Conclusions<\/jats:italic>: Our results demonstrate functional plasticity of the autonomic nervous system in response to normal physiological stimuli, and interaction between the nervous and immune systems during the immune response. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ar.1092430208","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T18:54:14Z","timestamp":1109444054000},"page":"208-222","source":"Crossref","is-referenced-by-count":4,"title":["Ultrastructural quantitative analysis of the innervation of axillary lymph nodes of the rat after antigenic stimulation"],"prefix":"10.1002","volume":"243","author":[{"given":"G. E. 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