{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T07:03:43Z","timestamp":1782889423355,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,1,26]],"date-time":"2005-01-26T00:00:00Z","timestamp":1106697600000},"content-version":"vor","delay-in-days":3374,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat. Rec."],"published-print":{"date-parts":[[1995,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background<\/jats:italic>: There is little agreement as to the secretory process of renin granules in juxtaglomerular granular cells (JG cells) of kidneys, although a large number of studies of the regulation of renin secretion have been reported.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>: The structural correlation between the stimuli and the secretory process was examined in mouse JG cells on renal cortical slice incubated with the beta\u2010adrenergic agonist, isoproterenol; the loop diuretic, furocemide; the Ca<jats:sup>2+<\/jats:sup> chelator, EGTA; and the actin filament\u2010disrupting agent, cytochalasin B.<\/jats:p><jats:p><jats:italic>Results and Conclusions<\/jats:italic>: Treatment with isoproterenol (10<jats:sup>\u22125<\/jats:sup>\u221210<jats:sup>\u22123<\/jats:sup> M) or furocemide (10<jats:sup>\u22123<\/jats:sup>M) in Ca<jats:sup>2+<\/jats:sup>\u2010containing medium did not significantly affect the ultrastructure of JG cells. In slices incubated with isoproterenol or furocemide in the Ca<jats:sup>2+<\/jats:sup>\u2010free medium, JG cells occasionally contained a few electron\u2010lucent granules at the cell periphery in addition to the electrondense mature granules observed in the control slices. On rare occasions, the JG cells displayed omega\u2010shaped cavities with electron\u2010lucent matrices, a feature similar to the contents of electron\u2010lucent granules. Cytochalasin B markedly promoted the effects of these stimulants in Ca<jats:sup>2+<\/jats:sup>\u2010free medium. These findings suggest the participation of actin filament disassembly in the exocytotic process of the mature granules in JG cells. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ar.1092430308","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T18:54:17Z","timestamp":1109444057000},"page":"336-346","source":"Crossref","is-referenced-by-count":10,"title":["Exocytosis of secretory granules in the juxtaglomerular granular cells of kidneys"],"prefix":"10.1002","volume":"243","author":[{"given":"Kazushige","family":"Ogawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maki","family":"Yamasato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyuki","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,1,26]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199003000-00004"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00338063"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01121449"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/319068a0"},{"key":"e_1_2_1_6_1","first-page":"F175","article-title":"Second messengers in renin secretion.","volume":"249","author":"Churchil P. 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