{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T01:09:25Z","timestamp":1760404165124},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,8,7]],"date-time":"2001-08-07T00:00:00Z","timestamp":997142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat. Rec."],"published-print":{"date-parts":[[2001,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The thyroid forms as an outpouching of the ventral pharynx. Evidence supports the conclusion that formation of the thyroid pit is mediated by changes in the cytoskeleton that cause constriction of cell apices. However, it seems unlikely that a relatively flat epithelial sheet can be converted into a pit without either distortions of the surface or considerable rearrangement of cells to reduce surface area. Possible cellular rearrangements were investigated by tracing the movements of individual cells by using time\u2010lapse video microscopy. Changes in shape of the primordium were investigated by marking with carbon and DiI and by scanning electron microscopy. Cell movements occurred only over short distances, mostly shifts relative to a neighbor, especially at the edge of the pit. Instead, cells rearranged into clusters that piled up at the edge of the pit and then tilted inside. Adjacent rings of pharyngeal cells were annexed by the growing thyroid, undergoing rearrangement into clusters, piling up at the edge, and moving inside the pit. The consequence was the formation of a series of shelf\u2010like extensions within the cavity, representing successive generations of cell rings moving inside. These results have implications for the formation of other organs by evagination. Anat Rec 264:146\u2013156, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ar.1140","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T21:24:42Z","timestamp":1030310682000},"page":"146-156","source":"Crossref","is-referenced-by-count":6,"title":["Cellular dynamics during evagination of the thyroid primordium in the chick embryo"],"prefix":"10.1002","volume":"264","author":[{"given":"Gwendolyn M.","family":"Kinebrew","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Robert","family":"Hilfer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,8,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511626173"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(68)90025-0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0040-8166(88)90015-8"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.480220709"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1050880104"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/13.4.1023"},{"key":"e_1_2_6_8_1","first-page":"1353","article-title":"Development of the eye of the chick embryo","volume":"3","author":"Hilfer SR","year":"1983","journal-title":"Scanning Electron Microsc"},{"key":"e_1_2_6_9_1","first-page":"2009","article-title":"The development of pharyngeal endocrine organs in mouse and chick embryos","author":"Hilfer SR","year":"1984","journal-title":"SEM"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/01902148609061488"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092270414"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1051740104"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.103.1.171"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.103.1.193"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1402510204"},{"key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1242\/jcs.49.1.15","article-title":"The movement of cell clusters in vitro: morphology and directionality","volume":"49","author":"Kolega J","year":"1981","journal-title":"J Cell Sci"},{"key":"e_1_2_6_17_1","first-page":"15","volume-title":"Cell\u2013Cell Interactions in Early Development","author":"McClay DR","year":"1991"},{"key":"e_1_2_6_18_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1242\/dev.105.1.17","article-title":"Shaping and bending of the avian neural plate as analyzed with a fluorescent\u2010histochemical marker","volume":"105","author":"Schoenwolf GC","year":"1989","journal-title":"Development"},{"key":"e_1_2_6_19_1","first-page":"325","article-title":"Epithelial cell wedging: a fundamental cell behavior contributing to hinge point formation during epithelial morphogenesis","volume":"1","author":"Schoenwolf GC","year":"1990","journal-title":"Semin Dev Biol"},{"key":"e_1_2_6_20_1","first-page":"427","article-title":"Neurulation in Xenopus laevis. An analysis and model based upon light and electron microscopy","volume":"23","author":"Schroeder TE","year":"1970","journal-title":"J Embryol Exp Morphol"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(72)90138-8"},{"key":"e_1_2_6_22_1","first-page":"513a","article-title":"A simple image analysis system using a microcomputer and video grabber board","volume":"103","author":"Sheffield JB","year":"1986","journal-title":"J Cell Biol"},{"key":"e_1_2_6_23_1","first-page":"456","article-title":"Digital image analyzer for the morphometric reconstruction of biological tissue","volume":"1","author":"Silage DA","year":"1982","journal-title":"Med Comp Sci"},{"key":"e_1_2_6_24_1","first-page":"269","article-title":"Patterns of cellular proliferation during thyroid organogenesis","volume":"48","author":"Smuts MS","year":"1978","journal-title":"J Embryol Exp Morphol"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/13.4.1007"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/38.5.2185313"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/13.4.1039"}],"container-title":["The Anatomical Record"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Far.1140","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.1140","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T20:06:30Z","timestamp":1697486790000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ar.1140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8,7]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,10]]}},"alternative-id":["10.1002\/ar.1140"],"URL":"https:\/\/doi.org\/10.1002\/ar.1140","archive":["Portico"],"relation":{},"ISSN":["0003-276X","1097-0185"],"issn-type":[{"value":"0003-276X","type":"print"},{"value":"1097-0185","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,8,7]]}}}