{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:36:49Z","timestamp":1761237409331,"version":"build-2065373602"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T00:00:00Z","timestamp":1171411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ataxia\u2010telangiectasia (A\u2010T) is a human autosomal recessive disorder characterized by neuronal degeneration as well as many other physiological and somatic defects. <jats:italic>ATM<\/jats:italic> (A\u2010T, mutated), the gene mutated in A\u2010T, encodes a 370 kDa protein kinase. <jats:italic>ATM<\/jats:italic> knockout mouse models (<jats:italic>ATM<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup>) show growth retardation, infertility, neurological dysfunction, defects in T\u2010lymphocytes, and extreme sensitivity to ionizing radiation. We have recently established multiple <jats:italic>ATM<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup> breeding pairs and discovered that all <jats:italic>ATM<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> offspring exhibit a nonpigmented section of tail, usually at or near the tip. To our knowledge, this is the first time that a phenotype of nonpigmented tail has been reported in <jats:italic>ATM<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> knockout mice. We believe that the sections of nonpigmented tail of 129S6\/SvEvTac\u2010<jats:italic>ATM<\/jats:italic><jats:sup>tm1Awb<\/jats:sup>\/J mice provide a novel phenotypic marker for research using this <jats:italic>ATM<\/jats:italic> knockout mouse model. Results from histochemistry and immunoblotting analysis further demonstrate that while melanocyte precursors or melanoblasts are present in the nonpigmented tail tissue of <jats:italic>ATM<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice, they fail to differentiate fully into mature melanocytes. The potential connection between this phenotype and other clinical symptoms caused by ATM deficiency, such as progressive neuronal degeneration, is discussed in this article. Anat Rec, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ar.20425","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T14:52:07Z","timestamp":1171464727000},"page":"243-250","source":"Crossref","is-referenced-by-count":3,"title":["A novel phenotypic marker for ATM\u2010deficient 129S6\/SvEvTac\u2010<i>ATM<\/i><sup>tm1Awb<\/sup>\/J mice"],"prefix":"10.1002","volume":"290","author":[{"given":"Jody C.","family":"Hibma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel A.","family":"Neufeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Jo","family":"Halaby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da\u2010Qing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,2,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.869001"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80086-0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.2.871"},{"volume-title":"Histological and histochemical techniques","year":"1960","author":"Davenport HA","key":"e_1_2_6_5_1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.23.13084"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-200008000-00001"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5366.1089"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ge.28.120194.001201"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/6.10.1613"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0021-9258(17)35295-X","article-title":"Tyrosinases from two different loci are expressed by normal and by transformed melanocytes","volume":"266","author":"Jimenez M","year":"1991","journal-title":"J Biol Chem"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2005.00231.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-17-06687.2001"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mop.0000171319.84053.45"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204565"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00762-6"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00281059"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400210"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.4.1676"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/7.10.1555"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7792600"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/4.11.2025"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1992.tb05082.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M410344200"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2005.00288.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.19.2411"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/35046542"}],"container-title":["The Anatomical Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Far.20425","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.20425","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:11:12Z","timestamp":1759939872000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/10.1002\/ar.20425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2,14]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["10.1002\/ar.20425"],"URL":"https:\/\/doi.org\/10.1002\/ar.20425","archive":["Portico"],"relation":{},"ISSN":["1932-8486","1932-8494"],"issn-type":[{"type":"print","value":"1932-8486"},{"type":"electronic","value":"1932-8494"}],"subject":[],"published":{"date-parts":[[2007,2,14]]}}}