{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T21:40:51Z","timestamp":1759959651333,"version":"build-2065373602"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,12,17]],"date-time":"2007-12-17T00:00:00Z","timestamp":1197849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Administration of thyroid hormone has been shown to accelerate the early postnatal development of the rat parotid gland, but these studies have dwelt almost entirely on biochemical changes. The objective of this study was to describe the effects of exogenous thyroid hormone on morphologic aspects of the developing parotid gland, in particular the transient appearance of scattered mucous cells in this otherwise serous gland. Pups were given a daily subcutaneous injection of thyroxine (T<jats:sub>4<\/jats:sub>) of 0.1, 0.5, or 5.0 \u03bcg\/g body weight, vehicle only (injection control), or no injection (normal control) beginning at 4 days, and killed for the collection of blood and parotid glands at intervals through 15 days. The serum was analyzed for T<jats:sub>4<\/jats:sub> and the glands were examined by light and electron microscopy. The results indicated that both serum T<jats:sub>4<\/jats:sub> and the pace of gland development were proportional to the dose of T<jats:sub>4<\/jats:sub>. In particular, T<jats:sub>4<\/jats:sub> accelerated decreases in acinar size and gland area occupied by stroma and translocation of a subset of cells with small secretory granules, deeply stained with periodic acid\u2013Schiff, from acini to intercalated ducts. However, the chronology of mucous cell disappearance was indifferent to treatment. In addition, signs of toxicity, including slower gain in body weight and greatly increased apoptosis and vacuoles in the glands, occurred with the higher doses of T<jats:sub>4<\/jats:sub>. Anat Rec, 291:94\u2013104, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ar.20620","type":"journal-article","created":{"date-parts":[[2007,12,17]],"date-time":"2007-12-17T15:47:23Z","timestamp":1197906443000},"page":"94-104","source":"Crossref","is-referenced-by-count":8,"title":["Effects of Exogenous Thyroid Hormone on the Postnatal Morphogenesis of the Rat Parotid Gland"],"prefix":"10.1002","volume":"291","author":[{"given":"Rie","family":"Ikeda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Aiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert S.","family":"Redman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,12,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-197509000-00012"},{"key":"e_1_2_6_3_1","first-page":"355","volume-title":"Biology of the salivary glands","author":"Ball WD","year":"1993"},{"key":"e_1_2_6_4_1","unstructured":"BallCN Connor\u2010LintonJ TaylorT.2003. Web chi square calculator. Available at:www.georgetown.edu\/cball\/webtools\/web_chi.html."},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-6480(74)90127-0"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/08959374900040010401"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1982.242.1.E33"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-110-3-1037"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.140.9.4221"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1373.1999.d01-50.x"},{"key":"e_1_2_6_11_1","first-page":"296","article-title":"Altered growth patterns and depressed pituitary growth hormone content in young rats: effects of pre\u2010 and postnatal thiouracil administration","volume":"46","author":"Froelich PA","year":"1982","journal-title":"Growth"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000055682"},{"key":"e_1_2_6_13_1","first-page":"86","article-title":"Reflex influences on watery vacuole formation in parotid acinar cells of rats","volume":"284","author":"Garrett JR","year":"1978","journal-title":"J Physiol"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00222633"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1679\/aohc.60.185"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0185(19990601)255:2<155::AID-AR5>3.0.CO;2-4"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00223536"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345870660023201"},{"key":"e_1_2_6_19_1","first-page":"502","article-title":"Cell cycle length and apoptosis in the developing rat parotid and sublingual glands","volume":"78","author":"Kruse DH","year":"1999","journal-title":"J Dent Res"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.0870065"},{"key":"e_1_2_6_21_1","first-page":"411","article-title":"Morphogenesis and functional differentiation of the rat parotid gland in vivo and in vitro","volume":"24","author":"Lawson KA","year":"1970","journal-title":"J Embryol Exp Morphol"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-0436.1994.56120075.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-123-5-2235"},{"key":"e_1_2_6_24_1","first-page":"161","volume-title":"Manual of histologic staining methods of the Armed Forces Institute of Pathology","author":"Luna LG","year":"1968"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(84)90406-5"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1963.tb16654.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/02713680500320711"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092130205"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.2307\/3579765"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0909-8836.2003.00087.x"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-108-3-1060"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1013636"},{"key":"e_1_2_6_33_1","first-page":"1","volume-title":"The salivary system","author":"Redman RS","year":"1987"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092350414"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.17.1.208"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(82)90182-0"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(76)90190-2"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0185(199811)252:3<485::AID-AR17>3.0.CO;2-J"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1679\/aohc1950.42.427"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1679\/aohc.64.259"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(77)90286-0"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01918854"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1159\/000198210"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(78)90365-3"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2005.31053"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-006-0111-3"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03350475"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1012281"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03348063"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.4.4.475"},{"key":"e_1_2_6_51_1","first-page":"26","volume-title":"The morphology of salivary glands","author":"Young JA","year":"1978"}],"container-title":["The Anatomical Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Far.20620","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.20620","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T21:04:45Z","timestamp":1759957485000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/10.1002\/ar.20620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,18]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1002\/ar.20620"],"URL":"https:\/\/doi.org\/10.1002\/ar.20620","archive":["Portico"],"relation":{},"ISSN":["1932-8486","1932-8494"],"issn-type":[{"type":"print","value":"1932-8486"},{"type":"electronic","value":"1932-8494"}],"subject":[],"published":{"date-parts":[[2007,12,18]]}}}