{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:03:34Z","timestamp":1791198214825,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2008,3,27]],"date-time":"2008-03-27T00:00:00Z","timestamp":1206576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the late Nineteenth Century, Santiago Ram\u00f3n y Cajal was able to reproduce an exceptional illustration of the Olfactory Nerve pathway and its myriad of cells, by using the Golgi Method. Dr. Cajal focused intense study on the histology of the nervous system and published a treatise on the olfactory nerve fibers and the distinct peripheral origin and central nervous system endpoint of this unique pathway. The original title of this work is \u201cOrigen y terminaci\u00f3n de las fibras nerviosas olfatorias\u201d published in 1890. As the original publication is in Spanish, here we provide an English translation allowing present\u2010day English speakers to read these writings. Cajal followed the trajectory of the olfactory nerve fibers as they transitioned between the peripheral and central nervous system and was able to assert that these fibers were not continuous from the olfactory bulb to the bipolar cells that relinquish into the olfactory epithelium, but that the olfactory system was made up of various cell types each having distinct morphologies and functions. This may very well be the first definitive description of the olfactory receptor neurons and the first illustrations of the continuity of these cells throughout the olfactory pathway. These meticulous histological preparations were created by first using Camillo Golgi's potassium dichromate and silver nitrate impregnation method known as \u201creazione nera\u201d or \u201cblack reaction,\u201d where nerve cells, nerve fibers, and neuroglia could be visualized. This study exhibits the structural and functional organization of the mammalian fila olfactoria as it was investigated in centuries past. Anat Rec, 291:741\u2010750, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ar.20660","type":"journal-article","created":{"date-parts":[[2008,3,27]],"date-time":"2008-03-27T14:18:48Z","timestamp":1206627528000},"page":"741-750","source":"Crossref","is-referenced-by-count":9,"title":["Origin and Endpoint of the Olfactory Nerve Fibers: As Described by Santiago Ram\u00f3n y Cajal"],"prefix":"10.1002","volume":"291","author":[{"given":"Catherine","family":"Levine","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Marcillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,3,27]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"Untersuchungen \u00fcber den Bau de Nasenschleimhaut 1862."},{"key":"e_1_2_6_3_2","unstructured":"Die Methylenblaufarbung als histologische MethodeAnatomischer Anzeiger 1887 p.130."},{"key":"e_1_2_6_4_2","unstructured":"Nuevas aplicaciones del m\u00e9todo de coloraci\u00f3n de Golgi Terminaciones del nervio olfatorio; etc. Septiembre 1889. Barcelona."},{"key":"e_1_2_6_5_2","unstructured":"Trait\u00e9 technique d'histologie 1888."},{"key":"e_1_2_6_6_2","unstructured":"The staining of the contents of the glandular tube using the rapid method which was first used by A. B\u00f6hm for hepatic ducts. Some time later and independent of B\u00f6hm we publishedNuevas aplicaciones del m\u00e9todo de Golgi(Sept. 1889). In this publication which we revealed this straightforward staining method by which not only the bile ducts could be stained but almost all of the glands (pancreas salivary testicular etc.). A. Oppel confirmed this interesing reaction in the bile ducts (Eine Methode zur Darstelleung feinerer Struckturverh\u00e4ltnisse der Leber.Anat. Anz.Mar. 1890) also confirmed by by Fusari y Panasci (Sulle Terminazions nervose nella mucosa e nelle ghiandole sierose della lingua etc. 1890) who have used the Golgi method to stain the serous glands of the mammalian tongue."},{"key":"e_1_2_6_7_2","unstructured":"Beitr\u00e4ge zur Kenntniss des Geruchsorgans des Hundes. Arch. f. mik. Anat. B. XXXIV1889. Dec."},{"key":"e_1_2_6_8_2","unstructured":"Lehrbuch der Histologie.1857 p.215."},{"key":"e_1_2_6_9_2","unstructured":"Ueber den feineren Bau des Bulbus olfactorius.Zeitsch. f. wissensch Zoologie. Bd. II."},{"key":"e_1_2_6_10_2","unstructured":"Ueber die feinere Structur der Lobi olfactorii M\u00fcller's Arch.1860p.469."},{"key":"e_1_2_6_11_2","unstructured":"Ueber den feinerem Bau des Bulbus olfactorius.Virchow's Arch.Bd. 22."},{"key":"e_1_2_6_12_2","unstructured":"Der Bau des Gross\u2010hirnrinde und seine Ortlichenverschiedenheiten etc\u00e9tera.Separatahsch. aus d. Vierteljahrschrift f\u00fcr Psychiatrie.1872."},{"key":"e_1_2_6_13_2","unstructured":"Handbuch der sistematischen Anatomie. Vol. III 1873 and Handbuch des Nervenlehre des Menschen (2 Abtheilung des 3.aBandes von Handbuch der Anat. 2 Auff.1879)."},{"key":"e_1_2_6_14_2","unstructured":"Sulla fina Struttura dei Bulbi olfatorii. Reggio\u2010Emilia.1875."},{"key":"e_1_2_6_15_2","unstructured":"Recherches sur les centres olfactifs. Revue d'anthropologie1879. p.389."},{"key":"e_1_2_6_16_2","unstructured":"Lehrbuch der Neurologie. Erlangen.1881."},{"key":"e_1_2_6_17_2","unstructured":"La Medicina pr\u00e1ctica n. 88. Conexi\u00f3n general de los elementos nerviosos."},{"key":"e_1_2_6_18_2","unstructured":"Notas preventivas sobre la estructura de los centros nerviosos.\u2013II. Estructura del bulbo olfatorio de las aves. Gac. Sanit. de Barcelona 10 Septiembre1890. (P. Ram\u00f3n)."}],"container-title":["The Anatomical Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Far.20660","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.20660","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T12:29:59Z","timestamp":1759926599000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/10.1002\/ar.20660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,27]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["10.1002\/ar.20660"],"URL":"https:\/\/doi.org\/10.1002\/ar.20660","archive":["Portico"],"relation":{},"ISSN":["1932-8486","1932-8494"],"issn-type":[{"value":"1932-8486","type":"print"},{"value":"1932-8494","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,27]]}}}