{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:26:06Z","timestamp":1790753166615,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,4,2]],"date-time":"2008-04-02T00:00:00Z","timestamp":1207094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Tight junctions (TJs) create a paracellular permeability barrier to restrict the passage of ions, small solutes, and water. Ameloblasts are enamel\u2010forming cells that sequentially differentiate into preameloblasts, secretory, transition, and ruffle\u2010ended and smooth\u2010ended maturation ameloblasts (RAs and SAs). TJs are located at the proximal and distal ends of ameloblasts. TJs at the distal ends of secretory ameloblasts and RAs are well\u2010developed zonula occludens, but other TJs are moderately developed but incomplete zonula occludens (ZO) or less\u2010developed macula occludens. We herein examined the immunofluorescence localization of TJ proteins, 10 claudin isoforms, occludin, ZO\u20101, and PAR3, a cell polarity\u2010related protein, in ameloblasts of rat upper incisors. ZO\u20101 and claudin\u20101 were detected at both ends of all ameloblasts except for the distal ends of SAs. Claudin\u20104 and occludin were detected at both ends of transition and maturation ameloblasts except for the distal ends of SAs. PAR3 was detected at the proximal TJs of all ameloblasts and faintly at the distal TJs of early RAs. These results indicate that functional zonula occludens formed at the distal ends of the secretory ameloblasts and RAs consisted of different TJ proteins. Therefore, the distal TJs of secretory ameloblasts and RAs may differentially regulate the paracellular permeability to create a microenvironment suitable for enamel deposition and enamel maturation, respectively. In addition, PAR3 may be principally involved in the formation and maintenance of the proximal, but not distal, TJs. Anat Rec, 291:577\u2013585, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ar.20683","type":"journal-article","created":{"date-parts":[[2008,4,2]],"date-time":"2008-04-02T13:31:54Z","timestamp":1207143114000},"page":"577-585","source":"Crossref","is-referenced-by-count":31,"title":["Differential Expression of the Tight Junction Proteins, Claudin\u20101, Claudin\u20104, Occludin, ZO\u20101, and PAR3, in the Ameloblasts of Rat Upper Incisors"],"prefix":"10.1002","volume":"291","author":[{"given":"Tetsuichiro","family":"Inai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihito","family":"Sengoku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Hirose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Iida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosaburo","family":"Shibata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,4,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2006.00497.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00038.2002"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.127.6.1617"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(07)00375-2"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.123.6.1631"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.141.1.199"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.115.12.2485"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1679\/aohc.60.297"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0171-9335(99)80086-7"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.138.1.181"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.147.6.1351"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.9.5981"},{"key":"e_1_2_5_14_1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00418-002-0482-3","article-title":"Expression 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