{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:13:03Z","timestamp":1759943583042,"version":"build-2065373602"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2008,6,2]],"date-time":"2008-06-02T00:00:00Z","timestamp":1212364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We examined the effects of glutathione (GSH) preconditioning through the portal vein on rat warm liver ischemia reperfusion injury (I\/R injury) and investigated the mechanisms involved. In rats with warm liver I\/R injury, administration of GSH by means of the portal vein before ischemia increased the 7\u2010day survival rates of rats after liver I\/R from 38% to 75%. This effect was correlated with significantly improved liver function, depressed MDA content in the liver and fewer histologic features of hepatocyte injury. Intrahepatic expression of P\u2010selectin and infiltration of neutrophils were increased significantly after liver I\/R. GSH pretreatment decreased intrahepatic MPO content and the expression of P\u2010selectin. However, it did not significantly affect the mRNA levels for P\u2010selectin after liver I\/R. Thus, preconditioning with GSH protects the liver against I\/R injury by a mechanism dependent on free radical species scavenging, down\u2010regulation of adhesion molecule expression and inhibition of neutrophil accumulation. These findings document the potential clinical utility of GSH to improve the overall success of diverse procedures, such as liver surgery and liver transplantation. Anat Rec, 291:1016\u20131022, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ar.20725","type":"journal-article","created":{"date-parts":[[2008,6,2]],"date-time":"2008-06-02T19:24:52Z","timestamp":1212434692000},"page":"1016-1022","source":"Crossref","is-referenced-by-count":10,"title":["Protective Effect of Glutathione Against Liver Warm Ischemia\u2010Reperfusion Injury in Rats is Associated with Regulation of P\u2010Selectin and Neutrophil 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