{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T18:29:56Z","timestamp":1774463396429,"version":"3.50.1"},"reference-count":90,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2008,6,2]],"date-time":"2008-06-02T00:00:00Z","timestamp":1212364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This work studies the structural and lectin\u2010binding modifications experienced by the renal corpuscle of the African lungfish <jats:italic>Protopterus dolloi<\/jats:italic> during aestivation. The kidney of the aestivating animals was studied by light\u2010 and electron\u2010microscopy, and by immunofluorescence methods. Upon aestivation, the renal corpuscles (RCs) undergo a marked size reduction, and all the structural RC components are affected. The parietal cells of Bowman's capsule lose their flattened appearance and adopt the organization of a stratified epithelium. The glomerular capillaries collapse. The podocytes approach each other. Concomitantly, the major processes between contiguous cells are lost, the rest of the major processes adopting a lamina\u2010like configuration. The foot processes lose their regular arrangement, the filtration slits are difficult to observe, and the subpodocyte space disappears. The glomerular basement membrane (GBM) thickens enormously, increases the amount of amorphous material and of collagen, and round inclusions formed by amorphous material and coiled fibrils appear. The mesangial cells compact and form a dense network embedded in the subendothelial lamina of the GBM. The endothelial cells show numerous irregularities, establishing abnormal interrelationships with the mesangial cells. These modifications are accompanied by changes in the expression of the carbohydrate moieties, as indicated by the modifications in lectin\u2010binding patterns. On the whole, these modifications thicken and compact the filtration barrier, thus reducing the filtration coefficient and allowing the organism to cope with dehydration. All these modifications are partially reversed during the first days of returning the animals to freshwater. The renal corpuscle appears to be a highly dynamic structure capable of modifying its architecture in response to environmental changes. Anat Rec, 291:1156\u20101172, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ar.20729","type":"journal-article","created":{"date-parts":[[2008,6,2]],"date-time":"2008-06-02T19:15:14Z","timestamp":1212434114000},"page":"1156-1172","source":"Crossref","is-referenced-by-count":26,"title":["Renal Corpuscle of the African Lungfish <i>Protopterus dolloi<\/i>: Structural and Histochemical Modifications During Aestivation"],"prefix":"10.1002","volume":"291","author":[{"given":"Jos\u00e9 L.","family":"Ojeda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wai P.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuen K.","family":"Ip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 M.","family":"Icardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,8,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2007.10.004"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00327750"},{"key":"e_1_2_6_4_1","first-page":"293","article-title":"Studies of kidney glomerular epithelial foot processes loss in the nephritic state and experimental situations","volume":"2","author":"Andrews PM","year":"1981","journal-title":"Biomed Res"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2741\/2044"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109723"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-6433(02)00004-1"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00216040"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00421.2006"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.00619"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.00813"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000164052"},{"key":"e_1_2_6_13_1","first-page":"5","article-title":"Biology of disease. Lectin cytochemistry and histochemistry","volume":"57","author":"Damjanov I","year":"1987","journal-title":"Lab Invest"},{"key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1242\/jeb.61.1.111","article-title":"Aestivation of the African lungfish Protopterus aethiopicus: cardiovascular and pulmonary function","volume":"61","author":"DeLaney RG","year":"1974","journal-title":"J Exp Biol"},{"key":"e_1_2_6_15_1","first-page":"R10","article-title":"Acid\u2010base balance and plasma composition in the estivating lungfish (Protopterus)","volume":"232","author":"DeLaney RG","year":"1977","journal-title":"Am J Physiol"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00209967"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V123413"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1076\/ejom.34.2.107.13017"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1051900416"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1051\/rnd:19890504"},{"key":"e_1_2_6_21_1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1242\/dev.108.2.313","article-title":"Early expresi\u00f3n of desmosomal components during kidney tubule morphogenesis in human and murine embryos","volume":"108","author":"Garrod DR","year":"1990","journal-title":"Development"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-449945-4.50007-5"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00215528"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1094-9194(02)00021-X"},{"key":"e_1_2_6_25_1","first-page":"209","volume-title":"Renal basement membranes in health and disease","author":"Grigorova\u2010Borsos AM","year":"1987"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0216098"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1139\/z68-061"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/31.4.6827083"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1972.117"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0922-3371(89)90737-5"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.a.160"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.a.237"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-406X(64)90098-2"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-406X(68)90800-1"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-406X(68)90799-8"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1994.39"},{"key":"e_1_2_6_37_1","first-page":"343","article-title":"Reduced sialylation of podocalyxin \u2010The major sialoprotein of the rat kidney glomerulus\u2010 in aminonucleoside nephrosis","volume":"118","author":"Kerjaschki D","year":"1985","journal-title":"Am J Pathol"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10077"},{"key":"e_1_2_6_39_1","first-page":"423","article-title":"Morphogenetic activity of extracellular matrices on cultured podocytes: laminin accelerates podocyte process formation in vitro","volume":"106","author":"Kobayashi N","year":"2001","journal-title":"Ital J Anat Embryol"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1994.47"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092230310"},{"key":"e_1_2_6_42_1","first-page":"3","volume-title":"Functional ultrastructure of the kidney","author":"Latta H","year":"1980"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2005.00385.x"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.55.070186.000343"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.a.147"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00360-007-0228-6"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1519-69842002000300014"},{"key":"e_1_2_6_48_1","first-page":"649","article-title":"Glomerular polyanions. Alterations in aminonucleoside nephrosis","volume":"23","author":"Michael AF","year":"1970","journal-title":"Lab Invest"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1999.9546"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0959-4493.2001.00272.x"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(81)90173-3"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1678"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(08)62509-7"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.3109\/10520298909107009"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00214432"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.a.10068"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.a.20333"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00020.2002"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2007.06.015"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00066.x"},{"key":"e_1_2_6_61_1","first-page":"1","article-title":"Revision systematique et raciation geographique des Protopteridae de l'Afrique Centrale","volume":"103","author":"Poll M","year":"1961","journal-title":"Ann Mus R Afr Ser Quart Zool"},{"key":"e_1_2_6_62_1","first-page":"157","article-title":"Glomerular epithelial cell changes after ischemia or deshydratation. Possible role of angiotensin II","volume":"114","author":"Racusen LC","year":"1984","journal-title":"Am J Pathol"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.57.070188.004033"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1080\/01913120490275240"},{"key":"e_1_2_6_65_1","first-page":"90","article-title":"Differentiation of epithelial foot processes and filtration slits: sequential appearance of occluding junctions, epithelial polyanion, and slit membranes in developing glomeruli","volume":"39","author":"Reeves W","year":"1978","journal-title":"Lab Invest"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1177\/10.3.250"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00187.2007"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2004.08.002"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(81)90273-3"},{"key":"e_1_2_6_70_1","first-page":"2361","article-title":"Control of renal functions in lungfishes","volume":"41","author":"Sawyer WH","year":"1982","journal-title":"Fed Proc"},{"key":"e_1_2_6_71_1","first-page":"48","article-title":"Pathogenesis of polycation\u2010induced alterations (\u201cfusion\u201d) of glomerular epithelium","volume":"36","author":"Seiler MW","year":"1977","journal-title":"Lab Invest"},{"key":"e_1_2_6_72_1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0021-9258(18)76799-9","article-title":"Metabolism of the lungfish Protopterus aethiopicus","volume":"88","author":"Smith HW","year":"1930","journal-title":"J Biol Chem"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1030060302"},{"key":"e_1_2_6_74_1","first-page":"1","volume-title":"Lectures on the Lawrence","author":"Smith HW","year":"1943"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(08)60416-7"},{"key":"e_1_2_6_76_1","first-page":"163","article-title":"Glomerular epithelial cell changes in early post\u2010ischemic acute renal failure in rabbits and man","volume":"103","author":"Solez K","year":"1981","journal-title":"Am J Pathol"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1139"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1679\/aohc.55.Suppl_147"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature730"},{"key":"e_1_2_6_80_1","first-page":"367","article-title":"The role of mast cells in wound healing","volume":"10","author":"Trabucchi E","year":"1988","journal-title":"Int J Tissue React"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(79)90166-0"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-200107000-00009"},{"key":"e_1_2_6_83_1","first-page":"54","article-title":"Effects of neuraminidase on lectin binding sites in photoreceptor cells of monkey retina","volume":"29","author":"Uehara S","year":"1985","journal-title":"Jpn J Ophthalmol"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1679\/aohc.54.427"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.a.20017"},{"key":"e_1_2_6_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00307231"},{"key":"e_1_2_6_87_1","doi-asserted-by":"publisher","DOI":"10.1086\/432919"},{"key":"e_1_2_6_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature729"},{"key":"e_1_2_6_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001380107"},{"key":"e_1_2_6_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00331191"},{"key":"e_1_2_6_91_1","first-page":"139","article-title":"Ultrastructure of the renal corpuscle of Testudo graeca (Chelonia). A comparison between hibernating and nonhibernating animals","volume":"1","author":"Zuasti A","year":"1986","journal-title":"Histol Histopathol"}],"container-title":["The Anatomical Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Far.20729","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.20729","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T11:47:52Z","timestamp":1759924072000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/10.1002\/ar.20729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8,25]]},"references-count":90,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["10.1002\/ar.20729"],"URL":"https:\/\/doi.org\/10.1002\/ar.20729","archive":["Portico"],"relation":{},"ISSN":["1932-8486","1932-8494"],"issn-type":[{"value":"1932-8486","type":"print"},{"value":"1932-8494","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8,25]]}}}