{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:40:11Z","timestamp":1791322811409,"version":"4.3.1"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,12,2]],"date-time":"2008-12-02T00:00:00Z","timestamp":1228176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Tabby\/eda mice, which bear a loss of function mutation for the <jats:italic>eda (ectodysplasinA)<\/jats:italic> gene, are known to display developmental anomalies in organs with an ectodermal origin. Although the lower jugal (cheek) teeth of Tabby\/eda mice have been extensively studied, upper teeth have never been investigated in detail. However, this may help us to further understand the function of the <jats:italic>eda<\/jats:italic> gene in tooth development. In this work, the shape and size of both the crown and the radicular system were studied in the Tabby\/eda mice upper jugal teeth. To deal with the high morphological variability, we defined several morphotypes based on cusp numbers and position. Statistical tests were then performed within and between the different morphotypes to test the correlation between tooth size and morphology. Our analysis reveals that, as in lower teeth, <jats:italic>eda<\/jats:italic> is necessary to segment the dental lamina into three teeth with the characteristic size and proportions of the mouse. Nevertheless, since strong effects are observed in heterozygous upper teeth while lower are only mildly affected, it seems that the upper jaw is more sensitive than the lower jaw to the loss of <jats:italic>eda<\/jats:italic> function. Modifications in cusp number and the abnormal crown size of the teeth are clearly linked, and our results indicate a role of <jats:italic>eda<\/jats:italic> in cusp patterning. Moreover, we found that the Tabby mutation induces variations in the dental root pattern, sometimes associated with hypercementosis, suggesting a newly uncovered role played by <jats:italic>eda<\/jats:italic> in root patterning and formation. Anat Rec, 2009. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ar.20804","type":"journal-article","created":{"date-parts":[[2008,12,2]],"date-time":"2008-12-02T12:36:25Z","timestamp":1228221385000},"page":"299-308","source":"Crossref","is-referenced-by-count":36,"title":["Effect of <i>eda<\/i> Loss of Function on Upper Jugal Tooth Morphology"],"prefix":"10.1002","volume":"292","author":[{"given":"Cyril","family":"Charles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Pantalacci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Peterkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Tafforeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Laudet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Viriot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,12,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12456718"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2754\/avb199867010003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.20437"},{"key":"e_1_2_7_5_1","first-page":"1","article-title":"Disruption of the palatal rugae pattern in Tabby (eda) mutant mice","volume":"114","author":"Charles C","year":"2007","journal-title":"Eur J Oral Sci"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2004.11.019"},{"key":"e_1_2_7_7_1","first-page":"659","volume-title":"Statistique th\u00e9orique et appliqu\u00e9e. 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