{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T16:50:36Z","timestamp":1771606236811,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,12,16]],"date-time":"2008-12-16T00:00:00Z","timestamp":1229385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The neuroanatomy of the ileocecal valve (ICV) is poorly understood. A better understanding of this important functional component of the gastrointestinal tract would enable surgeons to reconstruct an effective valve following surgical resection of the ICV. ICVs were examined in young pigs (N = 5) using frontal and transverse paraffin embedded and frozen sections. Hematoxylin+Eosin (H+E) staining, acetylcholinesterase (AchE), and NADPH\u2010diaphorase (NADPH\u2010d) histochemistry and protein gene product 9.5 (PGP 9.5) and C\u2010kit immunohistochemistry were performed. The H+E staining revealed that the ICV consists of three muscle layers: an external circular muscle layer continuous with that of the ileal circular muscle layer, an inner circular muscle layer continuous with that of the cecal circular muscle layer, and a single longitudinal muscle layer, which appears to be secondary to a fusion of the ileal and cecal longitudinal muscle layers. The AchE, NADPH\u2010d, and PGP 9.5 staining revealed two distinct coaxial myenteric plexuses, together with superficial and deep submucosal plexuses. The C\u2010kit immunostaining showed a continuous myenteric ICC network within the ICV. The structure of the neuromuscular components within the ICV suggests that the valve is a result of a simple intussusception of the terminal ileum into the cecum. This knowledge may help surgeons in their future attempts at reconstructing more anatomically and functionally suitable ICVs following surgical resection of native ICVs. Anat Rec 2009. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ar.20839","type":"journal-article","created":{"date-parts":[[2008,12,18]],"date-time":"2008-12-18T18:33:59Z","timestamp":1229625239000},"page":"254-261","source":"Crossref","is-referenced-by-count":17,"title":["New Insights into the Neuromuscular Anatomy of the Ileocecal Valve"],"prefix":"10.1002","volume":"292","author":[{"given":"Tamas","family":"Cserni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sri","family":"Paran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsolt","family":"Kanyari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2010Marie","family":"O'Donnell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balazs","family":"Kutasy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Nemeth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prem","family":"Puri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,12,16]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"857","article-title":"Distribution and localization of nitric oxide containing neural elements in the digestive tract","volume":"137","author":"Altdorfer K","year":"1996","journal-title":"Orv Hetil"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.3748\/wjg.v13.i20.2855","article-title":"A New concept of ileocecal junction: intussusception of the terminal ileum into the cecum","volume":"13","author":"Awapittaya B","year":"2007","journal-title":"World J Gastroenterol"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655200750024173"},{"key":"e_1_2_5_5_1","first-page":"561","article-title":"The ileocaecal junction","volume":"8","author":"Bogers JJ","year":"1993","journal-title":"Histol Histopathol"},{"key":"e_1_2_5_6_1","first-page":"93","article-title":"Structure and innervation of the musculature at the gastroduodenal junction of the guinea\u2010pig","volume":"139","author":"Cai WQ","year":"1984","journal-title":"J Anat"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1975.228.4.1075"},{"key":"e_1_2_5_8_1","first-page":"G894","article-title":"Pathways of slow\u2010wave propagation in proximal colon of cats","volume":"258","author":"Conklin JL","year":"1990","journal-title":"Am J Physiol"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/08941930591004458"},{"key":"e_1_2_5_10_1","first-page":"52","volume-title":"The sphincters of the digestive system. 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