{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T18:40:22Z","timestamp":1759948822402,"version":"build-2065373602"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,5,21]],"date-time":"2009-05-21T00:00:00Z","timestamp":1242864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\u03b2\u2010catenin functions as both a structural protein and a transcriptional activator. In this study, we examined the expression of \u03b2\u2010catenin in human cirrhotic livers, and administered adenoviruses carrying the \u03b2\u2010catenin or \u0394TCF4 genes to cirrhotic rats to investigate the role of \u03b2\u2010catenin in the development of liver cirrhosis development. \u03b2\u2010catenin expression was associated with liver cirrhosis development in cirrhotic human and rat liver. \u03b2\u2010catenin adenovirus was capable of accelerating cirrhosis progress but this progression was unaffected by administration of \u0394TCF4 adenovirus. \u03b2\u2010catenin was mainly located in the intercellular regions between liver cells and was highly concentrated in the hepatic sinusoid wall, where \u03b1\u2010smooth muscle actin (SMA) was also mainly distributed. The binding of \u03b2\u2010catenin to \u03b1\u2010SMA was also increased in cirrhotic liver. Portal vein blood pressure was significantly increased in the group administered \u03b2\u2010catenin adenovirus, but not in that receiving \u0394TCF4 adenovirus. These results suggest that high concentrations of \u03b2\u2010catenin at the hepatic intercellular membrane and the hepatic sinusoid wall contribute to hepatic hyperpiesia in liver cirrhosis patients. \u03b2\u2010catenin functions as a structural molecule, but not as a signaling molecule, during liver cirrhosis development. Anat Rec, 292:818\u2013826, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ar.20897","type":"journal-article","created":{"date-parts":[[2009,5,26]],"date-time":"2009-05-26T07:58:26Z","timestamp":1243324706000},"page":"818-826","source":"Crossref","is-referenced-by-count":3,"title":["Overexpression of \u03b2\u2010Catenin is Responsible for the Development of Portal Hypertension During Liver 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