{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T11:00:07Z","timestamp":1788865207984,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,4,20]],"date-time":"2009-04-20T00:00:00Z","timestamp":1240185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In permissive tissues, such as the gut and synovium, chronic inflammation can result in the ectopic development of anatomic structures that resemble lymph nodes. These inflammation\u2010induced structures, termed lymphoid neogenesis or tertiary lymphoid organs, may reflect differential stromal responsiveness to the process of lymphoid neogenesis. To investigate the structural reorganization of the microcirculation involved in colonic lymphoid neogenesis, we studied a murine model of dextran sodium sulfate (DSS)\u2010induced colitis. Standard 2\u2010dimensional histology demonstrated both submucosal and intramucosal lymphoid structures in DSS\u2010induced colitis. A spatial frequency analysis of serial histologic sections suggested that most intramucosal lymphoid aggregates developed <jats:italic>de novo<\/jats:italic>. Intravital microscopy of intravascular tracers confirmed that the developing intramucosal aggregates were supplied by capillaries arising from the quasi\u2010polygonal mucosal plexus. Confocal optical sections and whole mount morphometry demonstrated capillary networks (185 \u00b1 46 \u03bcm diameter) involving six to ten capillaries with a luminal diameter of 6.8 \u00b1 1.1 \u03bcm. Microdissection and angiogenesis PCR array analysis demonstrated enhanced expression of multiple angiogenic genes including CCL2, CXCL2, CXCL5, Il\u20101b, MMP9, and TNF within the mucosal plexus. Intravital microscopy of tracer particle flow velocities demonstrated a marked decrease in flow velocity from 808 \u00b1 901 \u03bcm\/sec within the feeding mucosal plexus to 491 \u00b1 155 \u03bcm\/sec within the capillary structures. We conclude that the development of ectopic lymphoid tissue requires significant structural remodeling of the stromal microcirculation. A feature of permissive tissues may be the capacity for lymphoid angiogenesis. Anat Rec, 292:621\u2013632, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ar.20902","type":"journal-article","created":{"date-parts":[[2009,4,21]],"date-time":"2009-04-21T01:18:53Z","timestamp":1240276733000},"page":"621-632","source":"Crossref","is-referenced-by-count":5,"title":["Vascular Microarchitecture of Murine Colitis\u2010Associated Lymphoid Angiogenesis"],"prefix":"10.1002","volume":"292","author":[{"given":"Aslihan","family":"Turhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace S.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lino 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