{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T01:08:55Z","timestamp":1759972135782,"version":"build-2065373602"},"reference-count":55,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,3,3]],"date-time":"2010-03-03T00:00:00Z","timestamp":1267574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Uterine natural killer (uNK) cells are the dominant lymphocytes of pregnant mammals' uterus. Studies have identified four differentiation stage of mouse uNK cells based on <jats:italic>Dolichos biflorus<\/jats:italic> lectin cytochemistry, and their distribution showed preferential domain in the uterus through out the pregnancy. This work was done to investigate the expression of \u03b15, \u03b16, and \u03b27 integrins on uNK cells and their ligands distribution. Section of mouse uterus from sixth to seventeenth gestational days were submitted to immunocytochemistry and positive reactions for \u03b15, \u03b16, and \u03b27 integrins were found on uNK from eighth to tenth gestational days but not after twelfth gestational days. Fibronectin reactions were seemed from sixth to tenth gestational days around uNK from the myometrium and endometrium close to the myometrium. No reaction for fibronectin was seen in the decidualized and nondecidualized endometrium near the placenta. Laminin reaction was seen just in the antimesometrial side. \u03b27 integrin seems to be the active receptor to bind with VCAM\u20101 or MAdCAM\u20101 of endothelial cells, promoting the uNK cross through the vessels. The absence of laminin in an uNK domain suggests these cells are not dependent of laminin and \u03b16 integrin for their establishment. However, fibronectin seems to support uNK migration, proliferation, differentiation, and survival in the uterus by binding with \u03b15 integrin. The loss of \u03b15 integrin ligation by the down regulation of fibronectin could inhibits these events and further studies are need to investigate whether unligated \u03b15 can actively and initiate apoptosis, maybe in a caspase 8\u2010dependent way that has been called integrin\u2010mediated death. Anat Rec, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ar.21117","type":"journal-article","created":{"date-parts":[[2010,3,3]],"date-time":"2010-03-03T12:14:27Z","timestamp":1267618467000},"page":"1081-1088","source":"Crossref","is-referenced-by-count":7,"title":["Immunocytochemical Studies of Adhesion Molecules on Mouse UNK Cells and Their Extracellular Matrix Ligands During Mouse Pregnancy"],"prefix":"10.1002","volume":"293","author":[{"given":"Bruno","family":"Zavan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9a Mollica Amarante","family":"Paffaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Pinto","family":"Joazeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ureo 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