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We show here in a murine model that <jats:italic>Fgf23<\/jats:italic> ablation disrupted morphology and protein expression within the dentoalveolar complex. Ectopic matrix formation in pulp chambers, odontoblast layer disruption, narrowing of periodontal ligament space, and alteration of cementum structure were observed in histological and electron microscopy sections. Because serum P<jats:sub>i<\/jats:sub> levels are dramatically elevated in <jats:italic>Fgf23<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic>, we assayed for apoptosis and expression of members from the small integrin\u2010binding ligand, N\u2010linked glycoprotein (SIBLING) family, both of which are sensitive to elevated P<jats:sub>i<\/jats:sub>\n<jats:italic>in vitro<\/jats:italic>. Unlike X\u2010linked hypophosphatemic (<jats:italic>Hyp)<\/jats:italic> and wild\u2010type (WT) specimens, numerous apoptotic osteocytes and osteoblasts were detected in <jats:italic>Fgf23<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic> specimens. Further, in comparison to <jats:italic>Hyp<\/jats:italic> and WT samples, decreased bone sialoprotein and elevated dentin matrix protein\u20101 protein levels were observed in cementum of <jats:italic>Fgf23<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic> mice. Additional dentin\u2010associated proteins, such as dentin sialoprotein and dentin phosphoprotein, exhibited altered localization in both <jats:italic>Fgf23<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic> and <jats:italic>Hyp<\/jats:italic> samples. Based on these results, we propose that FGF23 and (P<jats:sub>i<\/jats:sub>) homeostasis play a significant role in maintenance of the dentoalveolar complex. Anat Rec 293:1214\u20131226, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ar.21152","type":"journal-article","created":{"date-parts":[[2010,4,13]],"date-time":"2010-04-13T16:00:04Z","timestamp":1271174404000},"page":"1214-1226","source":"Crossref","is-referenced-by-count":27,"title":["Ablation of Systemic Phosphate\u2010Regulating Gene Fibroblast Growth Factor 23 (<i>Fgf23<\/i>) Compromises the Dentoalveolar 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