{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T01:03:12Z","timestamp":1759971792021,"version":"build-2065373602"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,3,31]],"date-time":"2011-03-31T00:00:00Z","timestamp":1301529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to assess the shape differences of the corpus callosum (CC) in patients with Beh\u00e7et's disease using statistical shape analysis (SSA). Additionally, an attempt was made to investigate the changes in CC size according to disease duration. Twenty\u2010five adults with clinically diagnosed Beh\u00e7et's disease and 25 age\u2010 and gender\u2010matched controls were examined by high\u2010resolution structural magnetic resonance imaging. The data obtained from the coordinate of landmarks were analyzed with Euclidean distance matrix analysis and a thin\u2010plate spline analysis. SSA and growth curve models were performed to investigate group differences and to fit the curves. A significant difference was determined between CC shape of Beh\u00e7et patients and controls (<jats:italic>P<\/jats:italic> = 0.006). Based on the analysis, a decrease occurred in the CC size of the Beh\u00e7et patients as the duration of disease increased. Maximum deformations were determined in the landmarks of interior notch of the splenium, inferior tip of the splenium, posterior\u2010most point of the CC, and topmost point of the CC. Similarly, the landmark of anterior\u2010most point of the CC was identified as having the minimum deformation. Beh\u00e7et patients had significantly different CC shapes from control subjects. The results suggest that SSA is a promising tool for distinguishing Beh\u00e7et patients from normal subjects, and that it can give useful information to assist clinicians. Additionally, SSA might be applied to detect shape differences in anatomical structures that are affected by a broad range of neurological diseases. Anat Rec, 2011. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ar.21373","type":"journal-article","created":{"date-parts":[[2011,3,31]],"date-time":"2011-03-31T10:27:45Z","timestamp":1301567265000},"page":"870-874","source":"Crossref","is-referenced-by-count":6,"title":["Detecting the Shape Differences of the Corpus Callosum in Beh\u00e7et's Disease by Statistical Shape Analysis"],"prefix":"10.1002","volume":"294","author":[{"given":"Cemil","family":"Colak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilker","family":"Ercan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Metin","family":"Dogan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Senem Turan","family":"Ozdemir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serpil","family":"Sener","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alpay","family":"Alkan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,3,31]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(99)00165-3"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073808318199"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-005-1370-z"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-003-1052-7"},{"volume-title":"Morphometrics tools for landmark data","year":"1991","author":"Bookstein FL","key":"e_1_2_5_6_1"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csda.2009.05.010"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1756-185X.2010.01462.x"},{"key":"e_1_2_5_9_1","first-page":"99","volume-title":"Assessment for counselors","author":"Dimitrov DM","year":"2006"},{"key":"e_1_2_5_10_1","unstructured":"DrydenIL.2009. Shapes: statistical shape analysis. R package version 1.1\u20133. Available at:http:\/\/cran.r\u2010project.org\/.Accessed on 10 June 2010."},{"volume-title":"Statistical shape analysis","year":"1998","author":"Dryden IL","key":"e_1_2_5_11_1"},{"key":"e_1_2_5_12_1","first-page":"51","article-title":"Adaptation of generalizability theory for inter\u2010rater reliability for landmark localization","volume":"9","author":"Ercan I","year":"2008","journal-title":"Int J Tomogr Stat"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchb.2004.07.004"},{"key":"e_1_2_5_14_1","first-page":"509","article-title":"Bernstein polynomial approach against to some frequently used growth curve models on animal data","volume":"26","author":"G\u00fcrcan M","year":"2010","journal-title":"Pak J Stat"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2010.05.006"},{"key":"e_1_2_5_16_1","first-page":"1078","article-title":"Criteria for diagnosis of Beh\u00e7et's disease","volume":"335","author":"International Study Group for Beh\u00e7et's disease","year":"1990","journal-title":"Lancet"},{"key":"e_1_2_5_17_1","first-page":"1015","article-title":"CNS involvement in neuro\u2010Beh\u00e7et syndrome: an MR study","volume":"20","author":"Ko\u00e7er N","year":"1999","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-820995"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/09273941003637510"},{"key":"e_1_2_5_20_1","article-title":"Semi\u2010automatic construction of reference standards for evaluation of image registration","author":"Murphy K","year":"2010","journal-title":"Med Image Anal"},{"key":"e_1_2_5_21_1","first-page":"493","article-title":"Geometric morphometric study and cluster analysis of Late Byzantine and modern human crania","volume":"34","author":"Ozdemir ST","year":"2010","journal-title":"Coll Antropol"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.20558"},{"issue":"1","key":"e_1_2_5_23_1","first-page":"249","article-title":"A new closed\u2010form information metric for shape analysis","volume":"9","author":"Peter A","year":"2006","journal-title":"Med Image Comput Comput Assist Interv"},{"key":"e_1_2_5_24_1","doi-asserted-by":"crossref","unstructured":"PolinaG GrimsonWEL ShentonME KikinisR.2001. Deformation analysis for shaped based classification information processing in medical imaging. In Proceedings of IPMI: International Conference on Information Processing and Medical Imaging LNCS 2082:517\u2013530.","DOI":"10.1007\/3-540-45729-1_54"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.an.21.100192.001435"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471725315"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004150050205"}],"container-title":["The Anatomical Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Far.21373","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.21373","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:50:10Z","timestamp":1759942210000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/10.1002\/ar.21373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,31]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["10.1002\/ar.21373"],"URL":"https:\/\/doi.org\/10.1002\/ar.21373","archive":["Portico"],"relation":{},"ISSN":["1932-8486","1932-8494"],"issn-type":[{"type":"print","value":"1932-8486"},{"type":"electronic","value":"1932-8494"}],"subject":[],"published":{"date-parts":[[2011,3,31]]}}}