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This is particularly important within the disciplines such as orthodontics and surgery, when dealing with mandibular defects due to tumors, developmental abnormalities, or trauma. In such cases, proper restorations of both form (for esthetic purposes) and function (restoration of articulation, occlusion, and mastication) are required. Several digital approaches based on three\u2010dimensional (3D) digital modeling, computer\u2010aided design (CAD)\/computer\u2010aided manufacturing techniques, and more recently geometric morphometric methods have been used to solve this problem. Nevertheless, comparisons among their outcomes are rarely provided. In this contribution, three methods for hemimandibular body reconstruction have been tested. Two bone defects were virtually simulated in a 3D digital model of a human hemimandible. Accordingly, 3D digital scaffolds were obtained using the mirror copy of the unaffected hemimandible (Method 1), the thin plate spline (TPS) interpolation (Method 2), and the combination between TPS and CAD techniques (Method 3). The mirror copy of the unaffected hemimandible does not provide a suitable solution for bone restoration. The combination between TPS interpolation and CAD techniques (Method 3) produces an almost perfect\u2010fitting 3D digital model that can be used for biocompatible custom\u2010made scaffolds generated by rapid prototyping technologies. Anat Rec, 2011. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ar.21410","type":"journal-article","created":{"date-parts":[[2011,5,25]],"date-time":"2011-05-25T11:33:15Z","timestamp":1306323195000},"page":"1116-1125","source":"Crossref","is-referenced-by-count":18,"title":["Comparing 3D Virtual Methods for Hemimandibular Body Reconstruction"],"prefix":"10.1002","volume":"294","author":[{"given":"Stefano","family":"Benazzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Fiorenza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Kozakowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ottmar","family":"Kullmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,5,25]]},"reference":[{"key":"e_1_2_7_2_1","article-title":"Free flap reconstruction of osteoradionecrosis of the mandible: a 10\u2010year review and defect classification","author":"Baumann DP","year":"2010","journal-title":"Head Neck"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jas.2010.01.018"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2010.02.028"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.20933"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00414-009-0339-6"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1109\/34.121791"},{"key":"e_1_2_7_8_1","volume-title":"Morphometric tools for landmark data. 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