{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:56:19Z","timestamp":1791158179497,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,6,29]],"date-time":"2011-06-29T00:00:00Z","timestamp":1309305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The forelimbs and hindlimbs of newborn <jats:italic>Polydactyly Nagoya<\/jats:italic> (<jats:italic>Pdn<\/jats:italic>) mice were examined to analyze the roles of programmed cell death (PCD) in the preaxial region of the limb. Special attention was paid to the relationship between the PCD in the preaxial area and the location and shape of the first digit (thumb\/big toe). Although a large, bifurcated or duplicated thumb\/big toe appeared in <jats:italic>Pdn<\/jats:italic>\/+ mice, digit I (thumb\/big toe) in <jats:italic>Pdn<\/jats:italic>\/+ mice, as in +\/+ ones, was located more ventro\u2010proximally than the other four digits. On the other hand, abnormal preaxial digits of the fore\/hindlimb in <jats:italic>Pdn\/Pdn<\/jats:italic> mice lay distally and were aligned at the radial\/tibial end of a serial curved plane formed by digits II\u2013V; that is, a thumb and big toe of normal shape and location were not detectable in any preaxial digits of <jats:italic>Pdn\/Pdn<\/jats:italic> mice. In the limb development of <jats:italic>Pdn<\/jats:italic> mouse embryos on Day 11\u201012, PCD did not occur in the preaxial mesoderm of fore\/hindlimb only in one\u2010fourths of all embryos obtained by <jats:italic>Pdn<\/jats:italic>\/+ x <jats:italic>Pdn<\/jats:italic>\/+ mating. In addition to digital rays II\u2010V, extra preaxial digital rays appeared in the prominent preaxial expansion of fore\/hindlimbs in these embryos on early Day 12. These abnormal limb configurations in embryos were closely similar to those in <jats:italic>Pdn\/Pdn<\/jats:italic> newborn mice. The present findings suggest that PCD in the preaxial region not only prevents the formation of extra digits but also determines the location of the thumb\/big toe for the normal limb morphogenesis. Anat Rec, 2011. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ar.21434","type":"journal-article","created":{"date-parts":[[2011,6,30]],"date-time":"2011-06-30T11:12:04Z","timestamp":1309432324000},"page":"1352-1359","source":"Crossref","is-referenced-by-count":5,"title":["Normal Location Of Thumb\/Big Toe may be Related to Programmed Cell Death in the Preaxial Area of Embryonic Limb"],"prefix":"10.1002","volume":"294","author":[{"given":"Sumiko","family":"Kimura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigehito","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Naruse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,6,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2907.1973.tb00178.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00174615"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21452"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cb.07.110191.003311"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1469-185X.1951.tb00774.x","article-title":"Cell 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