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A closer examination of surface discontinuity seems appropriate. Histological and atomic level analysis of bone alterations misses the forest for the trees and the former destroys the very subject it attempts to characterize. Surface discontinuity was therefore evaluated at the three\u2010dimensional submacroscopic level. An epifluorescent\/illumination microscope was used to characterize surface discontinuity in intact specimens of known pathophysiology and\/or derivation. The derived perspectives were then utilized to characterize other surface discontinuity. The smooth boundaries of vascular foramen and internal bifurcation, continuity of the expanded base of nerve structures and surrounding elevated rings of Sharpey fibers are all clearly distinguishable from fronts of resorption in erosive arthritis, serpentine discontinuity associated with infectious processes, specific zones of resorption noted in tuberculosis, and structural bone exposure by taphonomic abrasion. These perspectives allow the bone pathology associated with hematoma to be characterized as accentuated Sharpey fiber insertions; maxillary and sphenoid surface discontinuity, as vascular in origin; and periosteal reaction, as manifest by superficial bifurcating channels and in\u2010growth, similar to healing trephanation. Epi\u2010illumination microscopy bridges macroscopic and histological examination, providing greater understanding of the pathology, at no cost to the integrity of the material studied. It explains a number of observed results, while providing discriminatory descriptions of phenomena for which pathophysiology has not yet been clarified. Anat Rec, 296:580\u2013589, 2013. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ar.22673","type":"journal-article","created":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T05:21:07Z","timestamp":1402291267000},"page":"580-589","source":"Crossref","is-referenced-by-count":9,"title":["Nondestructive, Epi\u2010Illumination Surface Microscopic Characterization of Surface Discontinuity in Bone: A New Approach Offers a Descriptive Vocabulary and New Insights"],"prefix":"10.1002","volume":"296","author":[{"given":"Bruce M.","family":"Rothschild","sequence":"first","affiliation":[{"name":"Biodiversity Institute University of Kansas  Lawrence Kansas"},{"name":"Carnegie Museum of Natural History Pittsburgh Pennsylvania"},{"name":"Northeast Ohio Medical University Rootstown 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