{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:21:22Z","timestamp":1764174082646,"version":"build-2065373602"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,4,8]],"date-time":"2013-04-08T00:00:00Z","timestamp":1365379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Melatonin (MLT) is an indolic hormone produced mainly by the pineal gland. Recent human and animal studies have shown that MLT exerts obvious oncostatic activity both <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. The purpose of this study was to investigate the antiproliferative effect of MLT on the murine foregastric carcinoma (MFC) cell and to determine the underlying molecular mechanism. Cell viability was determined using the Cell Counting Kit\u20108 (CCK\u20108) and the results revealed that MLT exhibited a dose\u2010 and time\u2010dependent inhibitory effect on MFC cell growth. Our studies also demonstrated upregulation of p21 and Bax and downregulation of Bcl\u20102 at both the mRNA and the protein levels in response to MLT treatment of MFC cells. These changes in the expression of these molecules were consistent with the results of the CCK\u20108. Furthermore, the mRNA and protein expression of membranous MLT receptors was also upregulated. Taken together, these results confirm the oncostatic effect of MLT in MFC cells and the expression of membranous MLT receptors is a potential approach to tumor cells in gastric cancer therapeutic treatment. Anat Rec, 296:914\u2013920, 2013. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ar.22689","type":"journal-article","created":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T05:22:01Z","timestamp":1402291321000},"page":"914-920","source":"Crossref","is-referenced-by-count":22,"title":["Growth\u2010Inhibitory Activity of Melatonin on Murine Foregastric Carcinoma Cells <i>In Vitro<\/i> and the Underlying Molecular Mechanism"],"prefix":"10.1002","volume":"296","author":[{"given":"Li","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Human Anatomy, Histology and Embryology, Key Laboratory of Ministry of Education for Gastrointestinal Cancer Neurobiology Research Center School of Basic Medical Sciences, Fujian Medical University Fuzhou Fujian People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, Histology and 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