{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T22:30:53Z","timestamp":1768689053064,"version":"3.49.0"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,4,8]],"date-time":"2013-04-08T00:00:00Z","timestamp":1365379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Anatomical Record"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The cat ventral oral pontine reticular nucleus (vRPO) is responsible for the generation and maintenance of rapid eye movement (REM) sleep. Hypothalamic neurons containing the peptide hypocretin\u20101 (also called orexin\u2010A) which will be herewith defined as orexinergic (Orx) neurons, occupy a pre\u2010eminent place in the integration and stabilization of arousal networks as well as in the physiopathology of narcolepsy\/cataplexy. In the previous investigations, low\u2010volume and dose microinjections of hypocretin\u20101 in cat vRPO produced a specific and significant suppression of REM sleep. The aim of this study is to map the hypothalamic Orx neurons that project to the vRPO and suppress REM sleep generation in the cat. Five adult cats received microinjections of the retrograde tracer cholera toxin (CTb) into the vRPO. Brains were processed employing both CTb staining and antiorexin\u2010A immunocytochemistry techniques. A large number of double\u2010labeled neurons (Orx\u2013CTb) intermingled with the single CTb\u2010positive and single Orx neurons were detected in the ipsilateral lateral, perifornical, dorsal, anterior, perimammillothalamic, and posterior hypothalamic areas but were very scarce in the paraventricular, dorsomedial, ventromedial, and periventricular hypothalamic nuclei. A considerable number of double\u2010labeled neurons were also observed in both the dorsal and the lateral hypothalamic areas in the contralateral hypothalamus. Our results suggest that the widely distributed Orx neuronal hypothalamic groups could physiologically inhibit REM sleep generation in vRPO. Anat Rec, 296:815\u2013821, 2013. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ar.22690","type":"journal-article","created":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T05:16:14Z","timestamp":1402290974000},"page":"815-821","source":"Crossref","is-referenced-by-count":6,"title":["Hypothalamic Hypocretinergic\/Orexinergic Neurons Projecting to the Oral Pontine Rapid Eye Movement Sleep Inducing Site in the Cat"],"prefix":"10.1002","volume":"296","author":[{"given":"Berta","family":"Garc\u00eda\u2010Garc\u00eda","sequence":"first","affiliation":[{"name":"Departamento de Anatom\u00eda Histolog\u00eda y Neurociencia, Facultad de Medicina, Universidad Aut\u00f3noma de Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Reinoso\u2010Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Departamento de Anatom\u00eda Histolog\u00eda y Neurociencia, Facultad de Medicina, Universidad Aut\u00f3noma de Madrid Madrid 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