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Therefore, it is widely considered as \u201ca brain inside the brain.\u201d Although this rostral region has the same origin and general layering as the other cerebral cortices, some distinctive features make it very profitable in experimentation in neurobiology: the sensory inputs are driven directly on its surface, the main output can be accessed anatomically, and new elements appear in it throughout adult life. These three morphological characteristics have been manipulated to analyze further the response of the whole OB. The present review offers a general outlook into the consequences of such experimentation in the anatomy, connectivity and neurochemistry of the OB after (a) sensory deprivation, mainly by naris occlusion; (b) olfactory deinnervation by means of olfactory epithelium damage, olfactory nerve interruption, or even olfactory tract disruption; (c) the removal of the principal neurons of the OB; and (d) management of the arrival of newborn interneurons from the rostral migratory stream. These experiments were performed using surgical or chemical methods, but also by means of the analysis of genetic models, some of whose olfactory components are missing, colorless or mismatching within the wild\u2010type scenario of odor processing. Anat Rec, 296:1383\u20101400, 2013. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ar.22748","type":"journal-article","created":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T05:18:41Z","timestamp":1402291121000},"page":"1383-1400","source":"Crossref","is-referenced-by-count":23,"title":["The Olfactory System as a Puzzle: Playing With Its Pieces"],"prefix":"10.1002","volume":"296","author":[{"given":"D.","family":"D\u00edaz","sequence":"first","affiliation":[{"name":"Laboratory of Neuronal Plasticity and Neurorepair Institute for Neuroscience of Castile and Leon (INCyL), Universidad de Salamanca Salamanca Spain"},{"name":"Area of Gene and Cell Therapy Institute of Biomedical Research of Salamanca, IBSAL Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Laboratory of Neuronal Plasticity and Neurorepair Institute for Neuroscience of Castile and Leon (INCyL), Universidad de Salamanca Salamanca Spain"},{"name":"Institute for Molecular and Cell Biology of the Cancer, IBMCC, CSIC\u2010Universidad de Salamanca Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Mu\u00f1oz\u2010Casta\u00f1eda","sequence":"additional","affiliation":[{"name":"Laboratory of Neuronal Plasticity and Neurorepair Institute for Neuroscience of Castile and Leon (INCyL), Universidad de Salamanca Salamanca Spain"},{"name":"Area of Gene and Cell Therapy Institute of Biomedical Research of Salamanca, IBSAL Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Baltan\u00e1s","sequence":"additional","affiliation":[{"name":"Laboratory of Neuronal Plasticity and Neurorepair Institute for Neuroscience of Castile and Leon (INCyL), Universidad de Salamanca Salamanca Spain"},{"name":"Institute for Molecular and Cell Biology of the Cancer, IBMCC, CSIC\u2010Universidad de Salamanca Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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